Generating intrathymic microenvironments to establish T-cell tolerance

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Generating intrathymic microenvironments to establish T-cell tolerance. / Anderson, Graham; Lane, Peter; Jenkinson, Eric.

In: Nature Reviews Immunology, Vol. 7, No. 12, 01.12.2007, p. 954-63.

Research output: Contribution to journalArticle

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@article{da2b78aa38b94024ab76fba5b432d7dc,
title = "Generating intrathymic microenvironments to establish T-cell tolerance",
abstract = "Alphabeta T cells pass through a series of lymphoid tissue stromal microenvironments to acquire self tolerance and functional competence. In the thymus, positive selection of the developing T-cell receptor repertoire occurs in the cortex, whereas events in the medulla purge the system of self reactivity. T cells that survive are exported to secondary lymphoid organs where they direct first primary and then memory immune responses. This Review focuses on the microenvironments that nurture T-cell development rather than on T cells themselves. We summarize current knowledge on the formation of thymic epithelial-cell microenvironments, and highlight similarities between the environments that produce T cells and those that select and maintain them during immune responses.",
author = "Graham Anderson and Peter Lane and Eric Jenkinson",
year = "2007",
month = dec,
day = "1",
doi = "10.1038/nri2187",
language = "English",
volume = "7",
pages = "954--63",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",
number = "12",

}

RIS

TY - JOUR

T1 - Generating intrathymic microenvironments to establish T-cell tolerance

AU - Anderson, Graham

AU - Lane, Peter

AU - Jenkinson, Eric

PY - 2007/12/1

Y1 - 2007/12/1

N2 - Alphabeta T cells pass through a series of lymphoid tissue stromal microenvironments to acquire self tolerance and functional competence. In the thymus, positive selection of the developing T-cell receptor repertoire occurs in the cortex, whereas events in the medulla purge the system of self reactivity. T cells that survive are exported to secondary lymphoid organs where they direct first primary and then memory immune responses. This Review focuses on the microenvironments that nurture T-cell development rather than on T cells themselves. We summarize current knowledge on the formation of thymic epithelial-cell microenvironments, and highlight similarities between the environments that produce T cells and those that select and maintain them during immune responses.

AB - Alphabeta T cells pass through a series of lymphoid tissue stromal microenvironments to acquire self tolerance and functional competence. In the thymus, positive selection of the developing T-cell receptor repertoire occurs in the cortex, whereas events in the medulla purge the system of self reactivity. T cells that survive are exported to secondary lymphoid organs where they direct first primary and then memory immune responses. This Review focuses on the microenvironments that nurture T-cell development rather than on T cells themselves. We summarize current knowledge on the formation of thymic epithelial-cell microenvironments, and highlight similarities between the environments that produce T cells and those that select and maintain them during immune responses.

U2 - 10.1038/nri2187

DO - 10.1038/nri2187

M3 - Article

C2 - 17992179

VL - 7

SP - 954

EP - 963

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

SN - 1474-1733

IS - 12

ER -