General Entry into o-,o’-Heteroatom-Linked N-(Hetero)aryl Imidazole Motifs by Gold-Catalysed Formal [3+2]-Dipolar Cycloaddition

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@article{5b10eb5a27564ad2ad97d8e332ae931a,
title = "General Entry into o-,o{\textquoteright}-Heteroatom-Linked N-(Hetero)aryl Imidazole Motifs by Gold-Catalysed Formal [3+2]-Dipolar Cycloaddition",
abstract = "A general redox-neutral approach into the o-,o{\textquoteright}-heteroatom-linked N-(hetero)aryl imidazole family of heteroaromatics has been developed. New types of heteroatom substituted carbimidoyl nitrenoids are efficiently realised from robust, bench-stable N-(heteroaryl) pyridinium N-aminides by formal gold-catalysed [3+2]-dipolar cycloadditions across ynamides. Broad structural variety and functional group tolerance allows rapid access into diverse functionalised scaffolds, as exemplified by the preparation of 8 different heteroaromatic cores.",
keywords = "cycloaddition, nucleophilic nitrenoids, dipoles, gold, nitrogen heterocycles",
author = "Paul Davies and {Garzon Sanz}, Miguel and {Martinez Arce}, Elsa and Raju Jannapureddy",
year = "2017",
month = apr,
day = "18",
doi = "10.1002/adsc.201700249",
language = "English",
journal = "Advanced Synthesis & Catalysis",
issn = "1615-4169",
publisher = "Wiley-VCH Verlag",

}

RIS

TY - JOUR

T1 - General Entry into o-,o’-Heteroatom-Linked N-(Hetero)aryl Imidazole Motifs by Gold-Catalysed Formal [3+2]-Dipolar Cycloaddition

AU - Davies, Paul

AU - Garzon Sanz, Miguel

AU - Martinez Arce, Elsa

AU - Jannapureddy, Raju

PY - 2017/4/18

Y1 - 2017/4/18

N2 - A general redox-neutral approach into the o-,o’-heteroatom-linked N-(hetero)aryl imidazole family of heteroaromatics has been developed. New types of heteroatom substituted carbimidoyl nitrenoids are efficiently realised from robust, bench-stable N-(heteroaryl) pyridinium N-aminides by formal gold-catalysed [3+2]-dipolar cycloadditions across ynamides. Broad structural variety and functional group tolerance allows rapid access into diverse functionalised scaffolds, as exemplified by the preparation of 8 different heteroaromatic cores.

AB - A general redox-neutral approach into the o-,o’-heteroatom-linked N-(hetero)aryl imidazole family of heteroaromatics has been developed. New types of heteroatom substituted carbimidoyl nitrenoids are efficiently realised from robust, bench-stable N-(heteroaryl) pyridinium N-aminides by formal gold-catalysed [3+2]-dipolar cycloadditions across ynamides. Broad structural variety and functional group tolerance allows rapid access into diverse functionalised scaffolds, as exemplified by the preparation of 8 different heteroaromatic cores.

KW - cycloaddition

KW - nucleophilic nitrenoids

KW - dipoles

KW - gold

KW - nitrogen heterocycles

U2 - 10.1002/adsc.201700249

DO - 10.1002/adsc.201700249

M3 - Article

JO - Advanced Synthesis & Catalysis

JF - Advanced Synthesis & Catalysis

SN - 1615-4169

ER -