General Entry into o-,o’-Heteroatom-Linked N-(Hetero)aryl Imidazole Motifs by Gold-Catalysed Formal [3+2]-Dipolar Cycloaddition

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

External organisations

  • School of Chemisty

Abstract

A general redox-neutral approach into the o-,o’-heteroatom-linked N-(hetero)aryl imidazole family of heteroaromatics has been developed. New types of heteroatom substituted carbimidoyl nitrenoids are efficiently realised from robust, bench-stable N-(heteroaryl) pyridinium N-aminides by formal gold-catalysed [3+2]-dipolar cycloadditions across ynamides. Broad structural variety and functional group tolerance allows rapid access into diverse functionalised scaffolds, as exemplified by the preparation of 8 different heteroaromatic cores.

Details

Original languageEnglish
JournalAdvanced Synthesis & Catalysis
Early online date18 Apr 2017
Publication statusE-pub ahead of print - 18 Apr 2017

Keywords

  • cycloaddition, nucleophilic nitrenoids, dipoles, gold, nitrogen heterocycles

ASJC Scopus subject areas