General Entry into o-,o’-Heteroatom-Linked N-(Hetero)aryl Imidazole Motifs by Gold-Catalysed Formal [3+2]-Dipolar Cycloaddition
Research output: Contribution to journal › Article › peer-review
Authors
Colleges, School and Institutes
External organisations
- School of Chemisty
Abstract
A general redox-neutral approach into the o-,o’-heteroatom-linked N-(hetero)aryl imidazole family of heteroaromatics has been developed. New types of heteroatom substituted carbimidoyl nitrenoids are efficiently realised from robust, bench-stable N-(heteroaryl) pyridinium N-aminides by formal gold-catalysed [3+2]-dipolar cycloadditions across ynamides. Broad structural variety and functional group tolerance allows rapid access into diverse functionalised scaffolds, as exemplified by the preparation of 8 different heteroaromatic cores.
Details
| Original language | English |
|---|---|
| Journal | Advanced Synthesis & Catalysis |
| Early online date | 18 Apr 2017 |
| Publication status | E-pub ahead of print - 18 Apr 2017 |
Keywords
- cycloaddition, nucleophilic nitrenoids, dipoles, gold, nitrogen heterocycles