TY - JOUR
T1 - Gene therapy for colorectal cancer
AU - Palmer, Daniel
AU - Chen, Ming-Jen
AU - Kerr, David
PY - 2002/12/1
Y1 - 2002/12/1
N2 - Gene therapy has been developed as a potential novel treatment modality for colorectal cancer. The preclinical data have been promising and several clinical trials are under way for colorectal cancer. Data from many phase 1 trials have proven the safety of the reagents, but have not yet demonstrated significant therapeutic benefit. In order to refine this approach, continuing efforts should be made to improve the antitumour potency, efficiency of gene delivery, and accuracy of gene targeting. It is likely that gene therapy will be integrated into pre-existing therapies including surgery, chemotherapy and radiotherapy to establish its niche in tomorrow's medicine.
AB - Gene therapy has been developed as a potential novel treatment modality for colorectal cancer. The preclinical data have been promising and several clinical trials are under way for colorectal cancer. Data from many phase 1 trials have proven the safety of the reagents, but have not yet demonstrated significant therapeutic benefit. In order to refine this approach, continuing efforts should be made to improve the antitumour potency, efficiency of gene delivery, and accuracy of gene targeting. It is likely that gene therapy will be integrated into pre-existing therapies including surgery, chemotherapy and radiotherapy to establish its niche in tomorrow's medicine.
UR - http://www.scopus.com/inward/record.url?scp=0036031630&partnerID=8YFLogxK
U2 - 10.1093/bmb/64.1.201
DO - 10.1093/bmb/64.1.201
M3 - Article
C2 - 12421734
SN - 1471-8391
SN - 1471-8391
SN - 1471-8391
VL - 64
SP - 201
EP - 225
JO - British Medical Bulletin
JF - British Medical Bulletin
ER -