Gaps in knowledge and future directions for the use of faecal microbiota transplant in the treatment of inflammatory bowel disease

Research output: Contribution to journalReview articlepeer-review

Authors

  • Mehmet Yalchin
  • Jonathan P Segal
  • Benjamin H Mullish
  • Julian R Marchesi
  • Ailsa L Hart

Colleges, School and Institutes

External organisations

  • St Mark's Hospital
  • Imperial College London
  • University of Birmingham

Abstract

Faecal microbiota transplant (FMT) has now been established into clinical guidelines for the treatment of recurrent and refractory Clostridioides difficile infection (CDI). Its therapeutic application in inflammatory bowel disease (IBD) is currently at an early stage. To date, there have been four randomized controlled trials for FMT in IBD and a multitude of observational studies. However, significant gaps in our knowledge regarding optimum methods for FMT preparation, technical aspects and logistics of its administration, as well as mechanistic underpinnings, still remain. In this article, we aim to highlight these gaps by reviewing evidence and making key recommendations on the direction of future studies in this field. In addition, we provide an overview of the current evidence of potential mechanisms of FMT in treating IBD.

Bibliographic note

© The Author(s), 2019.

Details

Original languageEnglish
Pages (from-to)1756284819891038
JournalTherapeutic Advances in Gastroenterology
Volume12
Publication statusPublished - 2019