Gain-of-function mutation of tristetraprolin impairs negative feedback control of macrophages in vitro, yet has overwhelmingly anti-inflammatory consequences in vivo.

Search results

• Finished

  Innovative approaches to improving the safety and efficacy of glucocorticoids

  Clark, A.

  ARTHRITIS RESEARCH CAMPAIGN

  1/06/12 → 15/10/17

  Project: Research

  • Tristetraprolin 100%
  • Dual Specificity Phosphatase 1 33%
  • p38 Mitogen-Activated Protein Kinases 22%
  • Macrophages 20%
  • Anti-Inflammatory Agents 18%

• MRC Centre For Immune Regulation (Linked to DCDF.RRAK10540) (Linked to 14810 & 14835)

  Jenkinson, E.

  Medical Research Council

  3/08/09 → 30/09/17

  Project: Research Councils

  • T-Lymphocytes 100%
  • Thymus Gland 67%
  • Endothelial Cells 43%
  • Stromal Cells 38%
  • Salmonella 33%