Functionalized flexible soft polymer optical fibers for laser photomedicine

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Functionalized flexible soft polymer optical fibers for laser photomedicine. / Jiang, Nan; Ahmed, Rajib; Rifat, Ahmmed A.; Guo, Jingjing; Yin, Yixia; Montelongo, Yunuen; Butt, Haider; Yetisen, Ali K.

In: Advanced Optical Materials, Vol. 6, No. 3, 1701118, 02.2018.

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Jiang, Nan ; Ahmed, Rajib ; Rifat, Ahmmed A. ; Guo, Jingjing ; Yin, Yixia ; Montelongo, Yunuen ; Butt, Haider ; Yetisen, Ali K. / Functionalized flexible soft polymer optical fibers for laser photomedicine. In: Advanced Optical Materials. 2018 ; Vol. 6, No. 3.

Bibtex

@article{14f98fafa2484e7f946e492d8fb556fc,
title = "Functionalized flexible soft polymer optical fibers for laser photomedicine",
abstract = "Optical waveguides allow propagating light through biological tissue in optogenetics and photomedicine applications. However, achieving efficient light delivery to deep tissues for long-term implantation has been limited with solid-state optical fibers. Here, a method is created to rapidly fabricate flexible, functionalized soft polymer optical fibers (SPOFs) coupled with silica fibers. A step-index core/cladded poly(acrylamide-co-poly(ethylene glycol) diacrylate)/Ca alginate SPOF is fabricated through free-radical polymerization in a mold. The SPOF is integrated with a solid-state silica fiber coupler for efficient light delivery. The cladded SPOF shows ≈1.5-fold increase in light propagation compared to the noncladded fiber. The optical loss of the SPOF is measured as 0.6 dB cm-1 at the bending angle of 70° and 0.28 dB cm-1 through a phantom tissue. The SPOF (inner {\O} = 200 μm) integrated with a 21 gauge needle (inner {\O} = 514 μm) is inserted within a porcine tissue. The intensity of light decreases ≈60%, as the SPOF is implanted as deep as 2 cm. Doped with fluorescent dye and gold nanoparticles, the SPOF fiber exhibits yellow-red and red illumination. Living cells can also be incorporated within the SPOF with viability. The flexible SPOFs may have applications in photodynamic light therapy, optical biosensors, and photomedicine.",
keywords = "Biomaterials, Optical fibers, Photomedicine, Photonics, Waveguides",
author = "Nan Jiang and Rajib Ahmed and Rifat, {Ahmmed A.} and Jingjing Guo and Yixia Yin and Yunuen Montelongo and Haider Butt and Yetisen, {Ali K.}",
year = "2018",
month = feb,
doi = "10.1002/adom.201701118",
language = "English",
volume = "6",
journal = "Advanced Optical Materials",
issn = "2195-1071",
publisher = "Wiley",
number = "3",

}

RIS

TY - JOUR

T1 - Functionalized flexible soft polymer optical fibers for laser photomedicine

AU - Jiang, Nan

AU - Ahmed, Rajib

AU - Rifat, Ahmmed A.

AU - Guo, Jingjing

AU - Yin, Yixia

AU - Montelongo, Yunuen

AU - Butt, Haider

AU - Yetisen, Ali K.

PY - 2018/2

Y1 - 2018/2

N2 - Optical waveguides allow propagating light through biological tissue in optogenetics and photomedicine applications. However, achieving efficient light delivery to deep tissues for long-term implantation has been limited with solid-state optical fibers. Here, a method is created to rapidly fabricate flexible, functionalized soft polymer optical fibers (SPOFs) coupled with silica fibers. A step-index core/cladded poly(acrylamide-co-poly(ethylene glycol) diacrylate)/Ca alginate SPOF is fabricated through free-radical polymerization in a mold. The SPOF is integrated with a solid-state silica fiber coupler for efficient light delivery. The cladded SPOF shows ≈1.5-fold increase in light propagation compared to the noncladded fiber. The optical loss of the SPOF is measured as 0.6 dB cm-1 at the bending angle of 70° and 0.28 dB cm-1 through a phantom tissue. The SPOF (inner Ø = 200 μm) integrated with a 21 gauge needle (inner Ø = 514 μm) is inserted within a porcine tissue. The intensity of light decreases ≈60%, as the SPOF is implanted as deep as 2 cm. Doped with fluorescent dye and gold nanoparticles, the SPOF fiber exhibits yellow-red and red illumination. Living cells can also be incorporated within the SPOF with viability. The flexible SPOFs may have applications in photodynamic light therapy, optical biosensors, and photomedicine.

AB - Optical waveguides allow propagating light through biological tissue in optogenetics and photomedicine applications. However, achieving efficient light delivery to deep tissues for long-term implantation has been limited with solid-state optical fibers. Here, a method is created to rapidly fabricate flexible, functionalized soft polymer optical fibers (SPOFs) coupled with silica fibers. A step-index core/cladded poly(acrylamide-co-poly(ethylene glycol) diacrylate)/Ca alginate SPOF is fabricated through free-radical polymerization in a mold. The SPOF is integrated with a solid-state silica fiber coupler for efficient light delivery. The cladded SPOF shows ≈1.5-fold increase in light propagation compared to the noncladded fiber. The optical loss of the SPOF is measured as 0.6 dB cm-1 at the bending angle of 70° and 0.28 dB cm-1 through a phantom tissue. The SPOF (inner Ø = 200 μm) integrated with a 21 gauge needle (inner Ø = 514 μm) is inserted within a porcine tissue. The intensity of light decreases ≈60%, as the SPOF is implanted as deep as 2 cm. Doped with fluorescent dye and gold nanoparticles, the SPOF fiber exhibits yellow-red and red illumination. Living cells can also be incorporated within the SPOF with viability. The flexible SPOFs may have applications in photodynamic light therapy, optical biosensors, and photomedicine.

KW - Biomaterials

KW - Optical fibers

KW - Photomedicine

KW - Photonics

KW - Waveguides

U2 - 10.1002/adom.201701118

DO - 10.1002/adom.201701118

M3 - Article

AN - SCOPUS:85039160233

VL - 6

JO - Advanced Optical Materials

JF - Advanced Optical Materials

SN - 2195-1071

IS - 3

M1 - 1701118

ER -