Functionalized flexible soft polymer optical fibers for laser photomedicine

Research output: Contribution to journalArticle

Authors

  • Nan Jiang
  • Ahmmed A. Rifat
  • Jingjing Guo
  • Yixia Yin
  • Yunuen Montelongo

Colleges, School and Institutes

External organisations

  • Wuhan University of Technology
  • The Australian National University
  • Tsinghua University
  • Universidad de la Salle Bajio
  • The Harvard-MIT Division of Health Sciences and Technology

Abstract

Optical waveguides allow propagating light through biological tissue in optogenetics and photomedicine applications. However, achieving efficient light delivery to deep tissues for long-term implantation has been limited with solid-state optical fibers. Here, a method is created to rapidly fabricate flexible, functionalized soft polymer optical fibers (SPOFs) coupled with silica fibers. A step-index core/cladded poly(acrylamide-co-poly(ethylene glycol) diacrylate)/Ca alginate SPOF is fabricated through free-radical polymerization in a mold. The SPOF is integrated with a solid-state silica fiber coupler for efficient light delivery. The cladded SPOF shows ≈1.5-fold increase in light propagation compared to the noncladded fiber. The optical loss of the SPOF is measured as 0.6 dB cm-1 at the bending angle of 70° and 0.28 dB cm-1 through a phantom tissue. The SPOF (inner Ø = 200 μm) integrated with a 21 gauge needle (inner Ø = 514 μm) is inserted within a porcine tissue. The intensity of light decreases ≈60%, as the SPOF is implanted as deep as 2 cm. Doped with fluorescent dye and gold nanoparticles, the SPOF fiber exhibits yellow-red and red illumination. Living cells can also be incorporated within the SPOF with viability. The flexible SPOFs may have applications in photodynamic light therapy, optical biosensors, and photomedicine.

Details

Original languageEnglish
Article number1701118
JournalAdvanced Optical Materials
Volume6
Issue number3
Early online date28 Dec 2017
Publication statusPublished - Feb 2018

Keywords

  • Biomaterials, Optical fibers, Photomedicine, Photonics, Waveguides