Functional consequences of the somatopause and its treatment

Andrew R Hoffman; Steven A Lieberman; Gail Butterfield; Janice Thompson; Raymond L Hintz; Gian Paolo Ceda; Robert Marcus

doi:10.1007/BF02778067

Functional consequences of the somatopause and its treatment

Andrew R Hoffman, Steven A Lieberman, Gail Butterfield, Janice Thompson, Raymond L Hintz, Gian Paolo Ceda, Robert Marcus

Sport, Exercise and Rehabilitation Sciences

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18 Citations (Scopus)

Abstract

The decline in the function of the growth hormone-releasing hormone, growth hormone, insulin-like growth factor (GHRH-GH-IGF) axis has been termed the somatopause. Many of the catabolic sequelae seen in normal aging has been attributed to this decrease in circulating GH and IGF-I. In order to provide hormone replacement therapy for the somatopause, elderly subjects have been treated with GH, IGF-I, or both hormones together. Whereas numerous beneficial effects on body composition, strength, and quality of life have been reported in some studies, other studies have reported only marginal functional improvements. Moreover, it is clear that both hormones can cause significant morbidity.

Original language	English
Pages (from-to)	73-76
Number of pages	4
Journal	Endocrine Abstracts
Volume	7
Issue number	1
DOIs	https://doi.org/10.1007/BF02778067
Publication status	Published - 1997

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abstract = "The decline in the function of the growth hormone-releasing hormone, growth hormone, insulin-like growth factor (GHRH-GH-IGF) axis has been termed the somatopause. Many of the catabolic sequelae seen in normal aging has been attributed to this decrease in circulating GH and IGF-I. In order to provide hormone replacement therapy for the somatopause, elderly subjects have been treated with GH, IGF-I, or both hormones together. Whereas numerous beneficial effects on body composition, strength, and quality of life have been reported in some studies, other studies have reported only marginal functional improvements. Moreover, it is clear that both hormones can cause significant morbidity.",

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AU - Hoffman, Andrew R

AU - Lieberman, Steven A

AU - Butterfield, Gail

AU - Thompson, Janice

AU - Hintz, Raymond L

AU - Ceda, Gian Paolo

AU - Marcus, Robert

PY - 1997

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AB - The decline in the function of the growth hormone-releasing hormone, growth hormone, insulin-like growth factor (GHRH-GH-IGF) axis has been termed the somatopause. Many of the catabolic sequelae seen in normal aging has been attributed to this decrease in circulating GH and IGF-I. In order to provide hormone replacement therapy for the somatopause, elderly subjects have been treated with GH, IGF-I, or both hormones together. Whereas numerous beneficial effects on body composition, strength, and quality of life have been reported in some studies, other studies have reported only marginal functional improvements. Moreover, it is clear that both hormones can cause significant morbidity.

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Functional consequences of the somatopause and its treatment

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