Functional and proliferative effects of repeated low-dose oral administration of furan in rat liver

Research output: Contribution to journalArticle

Authors

  • A Mally
  • C Graff
  • O Schmal
  • S Moro
  • C Hamberger
  • UM Schauer
  • J Brueck
  • S Oezden
  • M Sieber
  • U Steger
  • D Schrenk
  • GC Hard
  • W Dekant

Colleges, School and Institutes

Abstract

Scope: Furan, a food contaminant formed during heat processing, induces hepatocellular tumors in rodents and high incidences of cholangiocarcinomas in rats even at the lowest dose (2 mg/kg b.w.) administered. Initial estimates suggested that human intake of furan may be as high as 3.5 mu g/kg b.w./day, indicating a relatively narrow margin of exposure. The aim of this study was to establish dose-response data for cytotoxicity, regenerative cell proliferation and secondary oxidative DNA damage in livers of male F344 rats treated with furan at doses

Details

Original languageEnglish
Pages (from-to)1556-1567
Number of pages12
JournalMolecular Nutrition & Food Research
Volume54
Issue number11
Publication statusPublished - 1 Nov 2010

Keywords

  • Carcinogenicity, Furan, liver, Cell proliferation