Functional and proliferative effects of repeated low-dose oral administration of furan in rat liver

A Mally; C Graff; O Schmal; S Moro; C Hamberger; UM Schauer; J Brueck; S Oezden; M Sieber; U Steger; D Schrenk; GC Hard; James Chipman; W Dekant

doi:10.1002/mnfr.201000064

Functional and proliferative effects of repeated low-dose oral administration of furan in rat liver

A Mally, C Graff, O Schmal, S Moro, C Hamberger, UM Schauer, J Brueck, S Oezden, M Sieber, U Steger, D Schrenk, GC Hard, James Chipman, W Dekant

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16 Citations (Scopus)

Abstract

Scope: Furan, a food contaminant formed during heat processing, induces hepatocellular tumors in rodents and high incidences of cholangiocarcinomas in rats even at the lowest dose (2 mg/kg b.w.) administered. Initial estimates suggested that human intake of furan may be as high as 3.5 mu g/kg b.w./day, indicating a relatively narrow margin of exposure. The aim of this study was to establish dose-response data for cytotoxicity, regenerative cell proliferation and secondary oxidative DNA damage in livers of male F344 rats treated with furan at doses

Original language	English
Pages (from-to)	1556-1567
Number of pages	12
Journal	Molecular Nutrition & Food Research
Volume	54
Issue number	11
DOIs	https://doi.org/10.1002/mnfr.201000064
Publication status	Published - 1 Nov 2010

Keywords

Carcinogenicity
Furan
liver
Cell proliferation

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10.1002/mnfr.201000064

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Mally, A., Graff, C., Schmal, O., Moro, S., Hamberger, C., Schauer, UM., Brueck, J., Oezden, S., Sieber, M., Steger, U., Schrenk, D., Hard, GC., Chipman, J., & Dekant, W. (2010). Functional and proliferative effects of repeated low-dose oral administration of furan in rat liver. Molecular Nutrition & Food Research, 54(11), 1556-1567. https://doi.org/10.1002/mnfr.201000064

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abstract = "Scope: Furan, a food contaminant formed during heat processing, induces hepatocellular tumors in rodents and high incidences of cholangiocarcinomas in rats even at the lowest dose (2 mg/kg b.w.) administered. Initial estimates suggested that human intake of furan may be as high as 3.5 mu g/kg b.w./day, indicating a relatively narrow margin of exposure. The aim of this study was to establish dose-response data for cytotoxicity, regenerative cell proliferation and secondary oxidative DNA damage in livers of male F344 rats treated with furan at doses ",

keywords = "Carcinogenicity, Furan, liver, Cell proliferation",

author = "A Mally and C Graff and O Schmal and S Moro and C Hamberger and UM Schauer and J Brueck and S Oezden and M Sieber and U Steger and D Schrenk and GC Hard and James Chipman and W Dekant",

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doi = "10.1002/mnfr.201000064",

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Mally, A, Graff, C, Schmal, O, Moro, S, Hamberger, C, Schauer, UM, Brueck, J, Oezden, S, Sieber, M, Steger, U, Schrenk, D, Hard, GC, Chipman, J & Dekant, W 2010, 'Functional and proliferative effects of repeated low-dose oral administration of furan in rat liver', Molecular Nutrition & Food Research, vol. 54, no. 11, pp. 1556-1567. https://doi.org/10.1002/mnfr.201000064

TY - JOUR

T1 - Functional and proliferative effects of repeated low-dose oral administration of furan in rat liver

AU - Mally, A

AU - Graff, C

AU - Schmal, O

AU - Moro, S

AU - Hamberger, C

AU - Schauer, UM

AU - Brueck, J

AU - Oezden, S

AU - Sieber, M

AU - Steger, U

AU - Schrenk, D

AU - Hard, GC

AU - Chipman, James

AU - Dekant, W

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Scope: Furan, a food contaminant formed during heat processing, induces hepatocellular tumors in rodents and high incidences of cholangiocarcinomas in rats even at the lowest dose (2 mg/kg b.w.) administered. Initial estimates suggested that human intake of furan may be as high as 3.5 mu g/kg b.w./day, indicating a relatively narrow margin of exposure. The aim of this study was to establish dose-response data for cytotoxicity, regenerative cell proliferation and secondary oxidative DNA damage in livers of male F344 rats treated with furan at doses

AB - Scope: Furan, a food contaminant formed during heat processing, induces hepatocellular tumors in rodents and high incidences of cholangiocarcinomas in rats even at the lowest dose (2 mg/kg b.w.) administered. Initial estimates suggested that human intake of furan may be as high as 3.5 mu g/kg b.w./day, indicating a relatively narrow margin of exposure. The aim of this study was to establish dose-response data for cytotoxicity, regenerative cell proliferation and secondary oxidative DNA damage in livers of male F344 rats treated with furan at doses

KW - Carcinogenicity

KW - Furan

KW - liver

KW - Cell proliferation

U2 - 10.1002/mnfr.201000064

DO - 10.1002/mnfr.201000064

M3 - Article

C2 - 20540150

VL - 54

SP - 1556

EP - 1567

JO - Molecular Nutrition & Food Research

JF - Molecular Nutrition & Food Research

IS - 11

ER -

Functional and proliferative effects of repeated low-dose oral administration of furan in rat liver

Abstract

Keywords

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