Fruit and vegetable intake and the risk of recurrence in patients with non-muscle invasive bladder cancer: a prospective cohort study

Research output: Contribution to journalArticle

Authors

  • Sylvia Jochems
  • Frits Van Osch
  • Mitch van Hensbergen
  • Duncan Nekeman
  • Anke Wesselius
  • Frederik-Jan van Schooten
  • D Michael A Wallace
  • Maurice Zeegers

Abstract

Introduction: There is some evidence that greater consumption of fruit and vegetables decreases the risk of bladder cancer. The role of fruit and vegetables in bladder cancer recurrence is still unknown.
Objective: The role of total fruit and vegetable intake in relation to the risk of developing bladder cancer recurrence in a prospective cohort study.
Methods: 728 patients with non-muscle invasive bladder cancer (NMIBC), who completed self-administrated questionnaires on fruit and vegetable intake at time of diagnosis (over the year before diagnosis) and one year after diagnosis, were included. Hazard ratios and 95% confidence intervals were calculated by multivariable Cox regression for developing recurrent bladder cancer in relation to fruit and vegetable intake.
Results: During 2,051 person-years of follow-up (mean (SD) follow-up 3.7 (1.5) years), 241 (33.1%) of the included 728 NMIBC patients developed a recurrence of bladder cancer. The sum of total fruit and vegetables before diagnosis was not related to a first bladder cancer recurrence (HR=1.07; 95% CI 0.78-1.47, p=0.66). No association was found between greater consumption of fruit and vegetables over the year before diagnosis and the risk of developing multiple recurrences of bladder cancer (HR= 1.02; 95% CI 0.90-1.15, p=0.78). Among the remaining 389 NMIBC patients who reported on fruit and vegetable intake one year after diagnosis, no association was found between greater consumption of fruit and vegetables and a first recurrence of bladder cancer (HR=0.65; 95% C.I. 0.42-1.01, p=0.06) nor with multiple recurrences of bladder cancer (HR= 1.00, 95% C.I. 0.85-1.18, p=1.00). Similar results were obtained when investigating the association between total intakes of fruit and vegetables separately and bladder cancer recurrence.
Conclusion: Results from this study did not indicate a protective role for total fruit and vegetables in the development of a recurrence of NMIBC.

Details

Original languageEnglish
Pages (from-to)573–579
JournalCancer Causes & Control
Volume29
Issue number6
Early online date17 Apr 2018
Publication statusPublished - Jun 2018