Fructose and Galactose Enhance Post-Exercise Human Liver Glycogen Synthesis.

Research output: Contribution to journalArticle


  • J Décombaz
  • R Jentjens
  • M Ith
  • E Scheurer
  • T Buehler
  • C Boesch

Colleges, School and Institutes


PURPOSE:: Both liver and muscle glycogen stores play a fundamental role in exercise and fatigue, but the effect of different carbohydrate (CHO) sources on liver glycogen synthesis in humans is unclear. The aim was to compare the effect of maltodextrin (MD) drinks containing galactose, fructose or glucose on post-exercise liver glycogen synthesis. METHODS:: In this double blind, triple cross-over, randomized clinical trial 10 well-trained male cyclists performed 3 experimental exercise sessions separated by at least 1 wk. After performing a standard exercise protocol to exhaustion, subjects ingested one of three 15% CHO solutions: FRU (MD+fructose 2:1), GAL (MD+galactose 2:1) or GLU (MD+glucose 2:1), each providing 69 g CHO·h during 6.5 h recovery. Liver glycogen changes were followed using C-magnetic resonance spectroscopy. RESULTS:: Liver glycogen concentration increased at faster rates with FRU (24 ± 2 mmol·L·h; P


Original languageEnglish
JournalMedicine and Science in Sports and Exercise
Publication statusPublished - 10 Mar 2011