From the regulation of peptidoglycan synthesis to bacterial growth and morphology

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From the regulation of peptidoglycan synthesis to bacterial growth and morphology. / Typas, Athanasios; Banzhaf, Manuel; Gross, Carol A; Vollmer, Waldemar.

In: Nature Reviews Microbiology, Vol. 10, No. 2, 28.12.2011, p. 123-36.

Research output: Contribution to journalReview article

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Typas, Athanasios ; Banzhaf, Manuel ; Gross, Carol A ; Vollmer, Waldemar. / From the regulation of peptidoglycan synthesis to bacterial growth and morphology. In: Nature Reviews Microbiology. 2011 ; Vol. 10, No. 2. pp. 123-36.

Bibtex

@article{dc1f40411ab547e084bf9f5e096705c0,
title = "From the regulation of peptidoglycan synthesis to bacterial growth and morphology",
abstract = "How bacteria grow and divide while retaining a defined shape is a fundamental question in microbiology, but technological advances are now driving a new understanding of how the shape-maintaining bacterial peptidoglycan sacculus grows. In this Review, we highlight the relationship between peptidoglycan synthesis complexes and cytoskeletal elements, as well as recent evidence that peptidoglycan growth is regulated from outside the sacculus in Gram-negative bacteria. We also discuss how growth of the sacculus is sensitive to mechanical force and nutritional status, and describe the roles of peptidoglycan hydrolases in generating cell shape and of D-amino acids in sacculus remodelling.",
keywords = "Amidohydrolases, Bacteria, Bacterial Outer Membrane Proteins, Bacterial Proteins, Cell Wall, Cytoskeletal Proteins, Cytoskeleton, Endopeptidases, Escherichia coli, Escherichia coli Proteins, Gene Expression Regulation, Bacterial, Gram-Negative Bacteria, Hydrolysis, N-Acetylmuramoyl-L-alanine Amidase, Peptidoglycan, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review",
author = "Athanasios Typas and Manuel Banzhaf and Gross, {Carol A} and Waldemar Vollmer",
year = "2011",
month = dec
day = "28",
doi = "10.1038/nrmicro2677",
language = "English",
volume = "10",
pages = "123--36",
journal = "Nature Reviews Microbiology",
issn = "1740-1526",
publisher = "Nature Publishing Group",
number = "2",

}

RIS

TY - JOUR

T1 - From the regulation of peptidoglycan synthesis to bacterial growth and morphology

AU - Typas, Athanasios

AU - Banzhaf, Manuel

AU - Gross, Carol A

AU - Vollmer, Waldemar

PY - 2011/12/28

Y1 - 2011/12/28

N2 - How bacteria grow and divide while retaining a defined shape is a fundamental question in microbiology, but technological advances are now driving a new understanding of how the shape-maintaining bacterial peptidoglycan sacculus grows. In this Review, we highlight the relationship between peptidoglycan synthesis complexes and cytoskeletal elements, as well as recent evidence that peptidoglycan growth is regulated from outside the sacculus in Gram-negative bacteria. We also discuss how growth of the sacculus is sensitive to mechanical force and nutritional status, and describe the roles of peptidoglycan hydrolases in generating cell shape and of D-amino acids in sacculus remodelling.

AB - How bacteria grow and divide while retaining a defined shape is a fundamental question in microbiology, but technological advances are now driving a new understanding of how the shape-maintaining bacterial peptidoglycan sacculus grows. In this Review, we highlight the relationship between peptidoglycan synthesis complexes and cytoskeletal elements, as well as recent evidence that peptidoglycan growth is regulated from outside the sacculus in Gram-negative bacteria. We also discuss how growth of the sacculus is sensitive to mechanical force and nutritional status, and describe the roles of peptidoglycan hydrolases in generating cell shape and of D-amino acids in sacculus remodelling.

KW - Amidohydrolases

KW - Bacteria

KW - Bacterial Outer Membrane Proteins

KW - Bacterial Proteins

KW - Cell Wall

KW - Cytoskeletal Proteins

KW - Cytoskeleton

KW - Endopeptidases

KW - Escherichia coli

KW - Escherichia coli Proteins

KW - Gene Expression Regulation, Bacterial

KW - Gram-Negative Bacteria

KW - Hydrolysis

KW - N-Acetylmuramoyl-L-alanine Amidase

KW - Peptidoglycan

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1038/nrmicro2677

DO - 10.1038/nrmicro2677

M3 - Review article

C2 - 22203377

VL - 10

SP - 123

EP - 136

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

SN - 1740-1526

IS - 2

ER -