From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal

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From pituitary adenoma to pituitary neuroendocrine tumor (PitNET) : an International Pituitary Pathology Club proposal. / Asa, S L; Karavitaki, Niki.

In: Endocrine-related cancer, Vol. 24, 01.04.2017, p. C5-C8.

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@article{8cfec1dbfa4d45e4a5fb92ea994bc6de,
title = "From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal",
abstract = "The classification of neoplasms of adenohypophysial cells is misleading because of the simplistic distinction between adenoma and carcinoma based solely on metastatic spread and the poor reproducibility and predictive value of the definition of atypical adenomas based on detection of mitoses or expression of Ki-67 or p53. In addition, the current classification of neoplasms of the anterior pituitary does not accurately reflect the clinical spectrum of behavior. Invasion and regrowth of proliferative lesions, and persistence of hormone hypersecretion cause significant morbidity and mortality. We propose a new terminology, pituitary neuroendocrine tumor (PitNET), which is consistent with that used for other neuroendocrine neoplasms and 38 which recognizes the highly variable impact of these tumors on patients. ",
keywords = "pituitary tumors, nomenclature",
author = "Asa, {S L} and Niki Karavitaki",
year = "2017",
month = apr,
day = "1",
doi = "10.1530/ERC-17-0004",
language = "English",
volume = "24",
pages = "C5--C8",
journal = "Endocrine-related cancer",
issn = "1351-0088",
publisher = "BioScientifica",

}

RIS

TY - JOUR

T1 - From pituitary adenoma to pituitary neuroendocrine tumor (PitNET)

T2 - an International Pituitary Pathology Club proposal

AU - Asa, S L

AU - Karavitaki, Niki

PY - 2017/4/1

Y1 - 2017/4/1

N2 - The classification of neoplasms of adenohypophysial cells is misleading because of the simplistic distinction between adenoma and carcinoma based solely on metastatic spread and the poor reproducibility and predictive value of the definition of atypical adenomas based on detection of mitoses or expression of Ki-67 or p53. In addition, the current classification of neoplasms of the anterior pituitary does not accurately reflect the clinical spectrum of behavior. Invasion and regrowth of proliferative lesions, and persistence of hormone hypersecretion cause significant morbidity and mortality. We propose a new terminology, pituitary neuroendocrine tumor (PitNET), which is consistent with that used for other neuroendocrine neoplasms and 38 which recognizes the highly variable impact of these tumors on patients.

AB - The classification of neoplasms of adenohypophysial cells is misleading because of the simplistic distinction between adenoma and carcinoma based solely on metastatic spread and the poor reproducibility and predictive value of the definition of atypical adenomas based on detection of mitoses or expression of Ki-67 or p53. In addition, the current classification of neoplasms of the anterior pituitary does not accurately reflect the clinical spectrum of behavior. Invasion and regrowth of proliferative lesions, and persistence of hormone hypersecretion cause significant morbidity and mortality. We propose a new terminology, pituitary neuroendocrine tumor (PitNET), which is consistent with that used for other neuroendocrine neoplasms and 38 which recognizes the highly variable impact of these tumors on patients.

KW - pituitary tumors

KW - nomenclature

U2 - 10.1530/ERC-17-0004

DO - 10.1530/ERC-17-0004

M3 - Article

VL - 24

SP - C5-C8

JO - Endocrine-related cancer

JF - Endocrine-related cancer

SN - 1351-0088

ER -