From cytokine to myokine: the emerging role of interleukin-6 in metabolic regulation

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From cytokine to myokine : the emerging role of interleukin-6 in metabolic regulation. / Pal, Martin; Febbraio, Mark A; Whitham, Martin.

In: Immunology and Cell Biology, Vol. 92, No. 4, 04.2014, p. 331-339.

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@article{925f57134af24a5c9dcd05e733733904,
title = "From cytokine to myokine: the emerging role of interleukin-6 in metabolic regulation",
abstract = "The lack of physical activity and overnutrition in our modern lifestyle culminates in what we now experience as the current obesity and diabetes pandemic. Medical research performed over the past 20 years identified chronic low-grade inflammation as a mediator of these metabolic disorders. Hence, finding therapeutic strategies against this underlying inflammation and identifying molecules implicated in this process is of significant importance. Following the observation of an increased plasma concentration of interleukin-6 (IL-6) in obese patients, this protein, known predominantly as a pro-inflammatory cytokine, came into focus. In an attempt to clarify its importance, several studies implicated IL-6 as a co-inducer of the development of obesity-associated insulin resistance, which precedes the development of type 2 diabetes. However, the identification of IL-6 as a myokine, a protein produced and secreted by skeletal muscle to fulfil paracrine or endocrine roles in the insulin-sensitizing effects following exercise, provides a contrasting and hence paradoxical identity of this protein in the context of metabolism. We review here the literature considering the complex, pleiotropic role of IL-6 in the context of metabolism in health and disease. ",
keywords = "Animals, Exercise, Humans, Immunity, Insulin Resistance, Interleukin-6/immunology, Metabolism/immunology, Muscle, Skeletal/immunology, Obesity/immunology",
author = "Martin Pal and Febbraio, {Mark A} and Martin Whitham",
year = "2014",
month = apr,
doi = "10.1038/icb.2014.16",
language = "English",
volume = "92",
pages = "331--339",
journal = "Immunology and Cell Biology",
issn = "0818-9641",
publisher = "Nature Publishing Group",
number = "4",

}

RIS

TY - JOUR

T1 - From cytokine to myokine

T2 - the emerging role of interleukin-6 in metabolic regulation

AU - Pal, Martin

AU - Febbraio, Mark A

AU - Whitham, Martin

PY - 2014/4

Y1 - 2014/4

N2 - The lack of physical activity and overnutrition in our modern lifestyle culminates in what we now experience as the current obesity and diabetes pandemic. Medical research performed over the past 20 years identified chronic low-grade inflammation as a mediator of these metabolic disorders. Hence, finding therapeutic strategies against this underlying inflammation and identifying molecules implicated in this process is of significant importance. Following the observation of an increased plasma concentration of interleukin-6 (IL-6) in obese patients, this protein, known predominantly as a pro-inflammatory cytokine, came into focus. In an attempt to clarify its importance, several studies implicated IL-6 as a co-inducer of the development of obesity-associated insulin resistance, which precedes the development of type 2 diabetes. However, the identification of IL-6 as a myokine, a protein produced and secreted by skeletal muscle to fulfil paracrine or endocrine roles in the insulin-sensitizing effects following exercise, provides a contrasting and hence paradoxical identity of this protein in the context of metabolism. We review here the literature considering the complex, pleiotropic role of IL-6 in the context of metabolism in health and disease.

AB - The lack of physical activity and overnutrition in our modern lifestyle culminates in what we now experience as the current obesity and diabetes pandemic. Medical research performed over the past 20 years identified chronic low-grade inflammation as a mediator of these metabolic disorders. Hence, finding therapeutic strategies against this underlying inflammation and identifying molecules implicated in this process is of significant importance. Following the observation of an increased plasma concentration of interleukin-6 (IL-6) in obese patients, this protein, known predominantly as a pro-inflammatory cytokine, came into focus. In an attempt to clarify its importance, several studies implicated IL-6 as a co-inducer of the development of obesity-associated insulin resistance, which precedes the development of type 2 diabetes. However, the identification of IL-6 as a myokine, a protein produced and secreted by skeletal muscle to fulfil paracrine or endocrine roles in the insulin-sensitizing effects following exercise, provides a contrasting and hence paradoxical identity of this protein in the context of metabolism. We review here the literature considering the complex, pleiotropic role of IL-6 in the context of metabolism in health and disease.

KW - Animals

KW - Exercise

KW - Humans

KW - Immunity

KW - Insulin Resistance

KW - Interleukin-6/immunology

KW - Metabolism/immunology

KW - Muscle, Skeletal/immunology

KW - Obesity/immunology

U2 - 10.1038/icb.2014.16

DO - 10.1038/icb.2014.16

M3 - Review article

C2 - 24751614

VL - 92

SP - 331

EP - 339

JO - Immunology and Cell Biology

JF - Immunology and Cell Biology

SN - 0818-9641

IS - 4

ER -