Frequency and impact of extracolonic findings detected at computed tomographic colonography in a symptomatic population
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Frequency and impact of extracolonic findings detected at computed tomographic colonography in a symptomatic population. / Khan, KY; Xiong, Tengbin; McCafferty, I; Riley, P; Ismail, Tariq; Lilford, Richard; Morton, Dion.
In: British Journal of Surgery, Vol. 94, No. 3, 01.03.2007, p. 355-361.Research output: Contribution to journal › Article
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T1 - Frequency and impact of extracolonic findings detected at computed tomographic colonography in a symptomatic population
AU - Khan, KY
AU - Xiong, Tengbin
AU - McCafferty, I
AU - Riley, P
AU - Ismail, Tariq
AU - Lilford, Richard
AU - Morton, Dion
PY - 2007/3/1
Y1 - 2007/3/1
N2 - BACKGROUND: Extracolonic findings are frequently recognized alongside colonic pathology at computed tomographic colonography (CTC). This study assessed the clinical impact of extracolonic findings in a symptomatic population at high risk of colorectal cancer. METHODS: CTC was performed in a consecutive cohort of patients assessed in a fast-track colorectal cancer clinic as being at high risk of colorectal cancer. A review of CTC findings and case notes was undertaken. Patients with extracolonic findings were followed up for at least 12 months. RESULTS: Thirty-one (13.8 per cent) of 225 patients investigated by CTC had colorectal cancer. Extracolonic findings were identified in 81 (53.3 per cent) of 152 patients with normal or non-neoplastic bowel findings, compared with 27 (37 per cent) of 73 patients with colorectal neoplasia (P = 0.025). Twenty-four patients (10.7 per cent) with extracolonic findings underwent further investigation or treatment. The median duration of investigation was 19.5 weeks. Seventy-five clinical events were recorded, including 14 surgical procedures. CONCLUSION: A prospective cost-benefit analysis of diagnostic CTC should be performed before it is established as a first-line investigation for colonic symptoms.
AB - BACKGROUND: Extracolonic findings are frequently recognized alongside colonic pathology at computed tomographic colonography (CTC). This study assessed the clinical impact of extracolonic findings in a symptomatic population at high risk of colorectal cancer. METHODS: CTC was performed in a consecutive cohort of patients assessed in a fast-track colorectal cancer clinic as being at high risk of colorectal cancer. A review of CTC findings and case notes was undertaken. Patients with extracolonic findings were followed up for at least 12 months. RESULTS: Thirty-one (13.8 per cent) of 225 patients investigated by CTC had colorectal cancer. Extracolonic findings were identified in 81 (53.3 per cent) of 152 patients with normal or non-neoplastic bowel findings, compared with 27 (37 per cent) of 73 patients with colorectal neoplasia (P = 0.025). Twenty-four patients (10.7 per cent) with extracolonic findings underwent further investigation or treatment. The median duration of investigation was 19.5 weeks. Seventy-five clinical events were recorded, including 14 surgical procedures. CONCLUSION: A prospective cost-benefit analysis of diagnostic CTC should be performed before it is established as a first-line investigation for colonic symptoms.
U2 - 10.1002/bjs.5498
DO - 10.1002/bjs.5498
M3 - Article
C2 - 17262750
VL - 94
SP - 355
EP - 361
JO - British Journal of Surgery
JF - British Journal of Surgery
SN - 0007-1323
IS - 3
ER -