Frequency analysis of involuntary movements during wrist tracking: A way to identify MS patients with tremor who benefit from thalamotomy

Research output: Contribution to journalArticlepeer-review


  • Xuguang Liu
  • Tipu Z. Aziz
  • Jeremy Rowe
  • Sundus H. Alusi
  • Peter G. Bain
  • John F. Stein

Colleges, School and Institutes

External organisations

  • University of Oxford
  • Radcliffe Infirmary
  • St Mark's NHS Trust


To identify those multiple sclerosis (MS) patients with disabling tremor who will benefit most from thalamotomy, measurements of frequency spectra of involuntary movements during visually guided wrist tracking were carried out in 11 consecutive patients with MS before and after ventrolateral thalamotomy. Thalamotomy was significantly more effective if patients had disruptive action tremor which appeared as a single peak in the frequency spectra. Such patients showed an average reduction of nearly 80% in tremor magnitude after thalamotomy. In comparison, surgery produced an average reduction of only 30% in 3 other patients who had action tremor but showed multiple peaks in the frequency spectra. Frequency analysis of involuntary movements identifies those MS patients with disabling tremor who benefited most from thalamotomy.


Original languageEnglish
Pages (from-to)53-62
Number of pages10
JournalStereotactic and Functional Neurosurgery
Issue number2
Publication statusPublished - 1 Dec 2000


  • Frequency spectrum, Multiple sclerosis, Thalamotomy, Tracking, Tremor

ASJC Scopus subject areas