Formulation of a covalently bonded hydroxyapatite and poly(ether ether ketone) composite

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@article{5e368ba7286241eba158f5d00de6d264,
title = "Formulation of a covalently bonded hydroxyapatite and poly(ether ether ketone) composite",
abstract = "Spinal fusion devices can be fabricated from composites based on combining hydroxyapatite and poly(ether ether ketone) phases. These implants serve as load-bearing scaffolds for the formation of new bone tissue between adjacent vertebrae. In this work, we report a novel approach to covalently bond hydroxyapatite and poly(ether ether ketone) to produce a novel composite formulation with enhanced interfacial adhesion between phases. Compared to non-linked composites (HA_PEEK), covalently linked composites (HA_L_PEEK), loaded with 1.25vol% hydroxyapatite, possessed a greater mean flexural strength (170±5.4 vs 171.7±14.8MPa (mean±SD)) and modulus (4.8±0.2 vs 5.0±0.3GPa (mean±SD)). Although the mechanical properties were not found to be significantly different (p>0.05), PEEK_L_HA contained substantially larger hydroxyapatite inclusions (100–1000 μm) compared to HA_PEEK (50–200 μm), due to the inherently agglomerative nature of the covalently bonded hydroxyapatite and poly(ether ether ketone) additive. Larger inclusions would expectedly weaken the HA_L_PEEK composite; however, there is no significant difference between the flexural modulus of poly(ether ether ketone) with respect to HA_L_PEEK (p=0.13). In addition, the flexural modulus of HA_PEEK is significantly lower compared to poly(ether ether ketone) (p = 0.03). Ultimately, covalent linking reduces hydroxyapatite particulate de-bonding from the polymeric matrix and inhibits micro-crack development, culminating in enhanced transfer of stiffness between hydroxyapatite and poly(ether ether ketone) under loading",
keywords = "poly(ether ether ketone), hydroxyapatitie, composite, spinal fusion",
author = "Erik Hughes and Andrew Parkes and Richard Williams and Michael Jenkins and Liam Grover",
year = "2019",
month = jan,
day = "1",
doi = "10.1177/2041731418815570",
language = "English",
volume = "9",
pages = "1--13",
journal = "Journal of Tissue Engineering",
issn = "2041-7314",
publisher = "SAGE Publications",

}

RIS

TY - JOUR

T1 - Formulation of a covalently bonded hydroxyapatite and poly(ether ether ketone) composite

AU - Hughes, Erik

AU - Parkes, Andrew

AU - Williams, Richard

AU - Jenkins, Michael

AU - Grover, Liam

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Spinal fusion devices can be fabricated from composites based on combining hydroxyapatite and poly(ether ether ketone) phases. These implants serve as load-bearing scaffolds for the formation of new bone tissue between adjacent vertebrae. In this work, we report a novel approach to covalently bond hydroxyapatite and poly(ether ether ketone) to produce a novel composite formulation with enhanced interfacial adhesion between phases. Compared to non-linked composites (HA_PEEK), covalently linked composites (HA_L_PEEK), loaded with 1.25vol% hydroxyapatite, possessed a greater mean flexural strength (170±5.4 vs 171.7±14.8MPa (mean±SD)) and modulus (4.8±0.2 vs 5.0±0.3GPa (mean±SD)). Although the mechanical properties were not found to be significantly different (p>0.05), PEEK_L_HA contained substantially larger hydroxyapatite inclusions (100–1000 μm) compared to HA_PEEK (50–200 μm), due to the inherently agglomerative nature of the covalently bonded hydroxyapatite and poly(ether ether ketone) additive. Larger inclusions would expectedly weaken the HA_L_PEEK composite; however, there is no significant difference between the flexural modulus of poly(ether ether ketone) with respect to HA_L_PEEK (p=0.13). In addition, the flexural modulus of HA_PEEK is significantly lower compared to poly(ether ether ketone) (p = 0.03). Ultimately, covalent linking reduces hydroxyapatite particulate de-bonding from the polymeric matrix and inhibits micro-crack development, culminating in enhanced transfer of stiffness between hydroxyapatite and poly(ether ether ketone) under loading

AB - Spinal fusion devices can be fabricated from composites based on combining hydroxyapatite and poly(ether ether ketone) phases. These implants serve as load-bearing scaffolds for the formation of new bone tissue between adjacent vertebrae. In this work, we report a novel approach to covalently bond hydroxyapatite and poly(ether ether ketone) to produce a novel composite formulation with enhanced interfacial adhesion between phases. Compared to non-linked composites (HA_PEEK), covalently linked composites (HA_L_PEEK), loaded with 1.25vol% hydroxyapatite, possessed a greater mean flexural strength (170±5.4 vs 171.7±14.8MPa (mean±SD)) and modulus (4.8±0.2 vs 5.0±0.3GPa (mean±SD)). Although the mechanical properties were not found to be significantly different (p>0.05), PEEK_L_HA contained substantially larger hydroxyapatite inclusions (100–1000 μm) compared to HA_PEEK (50–200 μm), due to the inherently agglomerative nature of the covalently bonded hydroxyapatite and poly(ether ether ketone) additive. Larger inclusions would expectedly weaken the HA_L_PEEK composite; however, there is no significant difference between the flexural modulus of poly(ether ether ketone) with respect to HA_L_PEEK (p=0.13). In addition, the flexural modulus of HA_PEEK is significantly lower compared to poly(ether ether ketone) (p = 0.03). Ultimately, covalent linking reduces hydroxyapatite particulate de-bonding from the polymeric matrix and inhibits micro-crack development, culminating in enhanced transfer of stiffness between hydroxyapatite and poly(ether ether ketone) under loading

KW - poly(ether ether ketone)

KW - hydroxyapatitie

KW - composite

KW - spinal fusion

UR - http://www.scopus.com/inward/record.url?scp=85060665663&partnerID=8YFLogxK

U2 - 10.1177/2041731418815570

DO - 10.1177/2041731418815570

M3 - Article

C2 - 30574291

VL - 9

SP - 1

EP - 13

JO - Journal of Tissue Engineering

JF - Journal of Tissue Engineering

SN - 2041-7314

ER -