Formin proteins in megakaryocytes and platelets: Regulation of actin and microtubule dynamics
Research output: Contribution to journal › Article
Colleges, School and Institutes
- Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham
The platelet and megakaryocyte cytoskeletons are essential for formation and function of these cells. A dynamic, properly organised tubulin and actin cytoskeleton is critical for the development of the megakaryocyte and the extension of proplatelets. Tubulin in particular plays a pivotal role in the extension of these proplatelets and the release of platelet from them. Tubulin is further required for the maintenance of platelet size and actin is the driving force for shape change, spreading and retraction during platelet activation. Whilst several key proteins which regulate these cytoskeletons have been described in detail, the formin family of proteins has received less attention. Formins are intriguing as, although they were initially believed to simply be a nucleator of actin polymerisation, increasing evidence shows they are important regulators of the cross talk between the actin and microtubule cytoskeletons. In this review we will introduce the formin proteins and consider the recent evidence that they play an important role in platelets and megakaryocytes in mediating both the actin and tubulin cytoskeletons.
|Early online date||18 Jun 2018|
|Publication status||E-pub ahead of print - 18 Jun 2018|
- formin , actin , microtubules cytoskeleton , proplatelet formation , macrothrombocytopenia