Focusing of sub-micrometer particles in microfluidic devices

Research output: Contribution to journalReview articlepeer-review

Standard

Focusing of sub-micrometer particles in microfluidic devices. / Zhang, Tianlong; Hong, Zhen-Yi; Tang, Shi-Yang; Li, Weihua; Inglis, David W.; Hosokawa, Yoichiroh; Yalikun, Yaxiaer; Li, Ming.

In: Lab on a Chip, Vol. 20, No. 1, 07.01.2020, p. 35-53.

Research output: Contribution to journalReview articlepeer-review

Harvard

Zhang, T, Hong, Z-Y, Tang, S-Y, Li, W, Inglis, DW, Hosokawa, Y, Yalikun, Y & Li, M 2020, 'Focusing of sub-micrometer particles in microfluidic devices', Lab on a Chip, vol. 20, no. 1, pp. 35-53. https://doi.org/10.1039/C9LC00785G

APA

Zhang, T., Hong, Z-Y., Tang, S-Y., Li, W., Inglis, D. W., Hosokawa, Y., Yalikun, Y., & Li, M. (2020). Focusing of sub-micrometer particles in microfluidic devices. Lab on a Chip, 20(1), 35-53. https://doi.org/10.1039/C9LC00785G

Vancouver

Zhang T, Hong Z-Y, Tang S-Y, Li W, Inglis DW, Hosokawa Y et al. Focusing of sub-micrometer particles in microfluidic devices. Lab on a Chip. 2020 Jan 7;20(1):35-53. https://doi.org/10.1039/C9LC00785G

Author

Zhang, Tianlong ; Hong, Zhen-Yi ; Tang, Shi-Yang ; Li, Weihua ; Inglis, David W. ; Hosokawa, Yoichiroh ; Yalikun, Yaxiaer ; Li, Ming. / Focusing of sub-micrometer particles in microfluidic devices. In: Lab on a Chip. 2020 ; Vol. 20, No. 1. pp. 35-53.

Bibtex

@article{3bbd342074044496b83303da57fd0a0b,
title = "Focusing of sub-micrometer particles in microfluidic devices",
abstract = "Sub-micrometer particles (0.10-1.0 μm) are of great significance to study, e.g., microvesicles and protein aggregates are targets for therapeutic intervention, and sub-micrometer fluorescent polystyrene (PS) particles are used as probes for diagnostic imaging. Focusing of sub-micrometer particles-precisely control over the position of sub-micrometer particles in a tightly focused stream-has a wide range of applications in the field of biology, chemistry and environment, by acting as a prerequisite step for downstream detection, manipulation and quantification. Microfluidic devices have been attracting great attention as desirable tools for sub-micrometer particle focusing, due to their small size, low reagent consumption, fast analysis and low cost. Recent advancements in fundamental knowledge and fabrication technologies have enabled microfluidic focusing of particles at sub-micrometer scale in a continuous, label-free and high-throughput manner. Microfluidic methods for the focusing of sub-micrometer particles can be classified into two main groups depending on whether an external field is applied: 1) passive methods, which utilize intrinsic fluidic properties without the need of external actuation, such as inertial, deterministic lateral displacement (DLD), viscoelastic and hydrophoretic focusing; and 2) active methods, where external fields are used, such as dielectrophoretic, thermophoretic, acoustophoretic and optical focusing. This article mainly reviews the studies on the focusing of sub-micrometer particles in microfluidic devices over the past 10 years. It aims to bridge the gap between the focusing of micrometer and nanometer scale (1.0-100 nm) particles and to improve the understanding of development progress, current advances and future prospects in microfluidic focusing techniques.",
author = "Tianlong Zhang and Zhen-Yi Hong and Shi-Yang Tang and Weihua Li and Inglis, {David W.} and Yoichiroh Hosokawa and Yaxiaer Yalikun and Ming Li",
year = "2020",
month = jan,
day = "7",
doi = "10.1039/C9LC00785G",
language = "English",
volume = "20",
pages = "35--53",
journal = "Lab on a Chip",
issn = "1473-0197",
publisher = "Royal Society of Chemistry",
number = "1",

}

RIS

TY - JOUR

T1 - Focusing of sub-micrometer particles in microfluidic devices

AU - Zhang, Tianlong

AU - Hong, Zhen-Yi

AU - Tang, Shi-Yang

AU - Li, Weihua

AU - Inglis, David W.

AU - Hosokawa, Yoichiroh

AU - Yalikun, Yaxiaer

AU - Li, Ming

PY - 2020/1/7

Y1 - 2020/1/7

N2 - Sub-micrometer particles (0.10-1.0 μm) are of great significance to study, e.g., microvesicles and protein aggregates are targets for therapeutic intervention, and sub-micrometer fluorescent polystyrene (PS) particles are used as probes for diagnostic imaging. Focusing of sub-micrometer particles-precisely control over the position of sub-micrometer particles in a tightly focused stream-has a wide range of applications in the field of biology, chemistry and environment, by acting as a prerequisite step for downstream detection, manipulation and quantification. Microfluidic devices have been attracting great attention as desirable tools for sub-micrometer particle focusing, due to their small size, low reagent consumption, fast analysis and low cost. Recent advancements in fundamental knowledge and fabrication technologies have enabled microfluidic focusing of particles at sub-micrometer scale in a continuous, label-free and high-throughput manner. Microfluidic methods for the focusing of sub-micrometer particles can be classified into two main groups depending on whether an external field is applied: 1) passive methods, which utilize intrinsic fluidic properties without the need of external actuation, such as inertial, deterministic lateral displacement (DLD), viscoelastic and hydrophoretic focusing; and 2) active methods, where external fields are used, such as dielectrophoretic, thermophoretic, acoustophoretic and optical focusing. This article mainly reviews the studies on the focusing of sub-micrometer particles in microfluidic devices over the past 10 years. It aims to bridge the gap between the focusing of micrometer and nanometer scale (1.0-100 nm) particles and to improve the understanding of development progress, current advances and future prospects in microfluidic focusing techniques.

AB - Sub-micrometer particles (0.10-1.0 μm) are of great significance to study, e.g., microvesicles and protein aggregates are targets for therapeutic intervention, and sub-micrometer fluorescent polystyrene (PS) particles are used as probes for diagnostic imaging. Focusing of sub-micrometer particles-precisely control over the position of sub-micrometer particles in a tightly focused stream-has a wide range of applications in the field of biology, chemistry and environment, by acting as a prerequisite step for downstream detection, manipulation and quantification. Microfluidic devices have been attracting great attention as desirable tools for sub-micrometer particle focusing, due to their small size, low reagent consumption, fast analysis and low cost. Recent advancements in fundamental knowledge and fabrication technologies have enabled microfluidic focusing of particles at sub-micrometer scale in a continuous, label-free and high-throughput manner. Microfluidic methods for the focusing of sub-micrometer particles can be classified into two main groups depending on whether an external field is applied: 1) passive methods, which utilize intrinsic fluidic properties without the need of external actuation, such as inertial, deterministic lateral displacement (DLD), viscoelastic and hydrophoretic focusing; and 2) active methods, where external fields are used, such as dielectrophoretic, thermophoretic, acoustophoretic and optical focusing. This article mainly reviews the studies on the focusing of sub-micrometer particles in microfluidic devices over the past 10 years. It aims to bridge the gap between the focusing of micrometer and nanometer scale (1.0-100 nm) particles and to improve the understanding of development progress, current advances and future prospects in microfluidic focusing techniques.

UR - http://www.scopus.com/inward/record.url?scp=85076823607&partnerID=8YFLogxK

U2 - 10.1039/C9LC00785G

DO - 10.1039/C9LC00785G

M3 - Review article

VL - 20

SP - 35

EP - 53

JO - Lab on a Chip

JF - Lab on a Chip

SN - 1473-0197

IS - 1

ER -