Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success
Research output: Contribution to journal › Article › peer-review
- University of Birmingham
Quinolone and fluoroquinolone antibiotics are potent, broad-spectrum agents commonly used to treat a range of infections. Resistance to these agents is multifactorial and can be via one or a combination of target-site gene mutations, increased production of multidrug-resistance (MDR) efflux pumps, modifying enzymes, and/or target-protection proteins. Fluoroquinolone-resistant clinical isolates of bacteria have emerged readily and recent data have shown that resistance to this class of antibiotics can have diverse, species-dependent impacts on host-strain fitness. Here we outline the impacts of quinolone-resistance mutations in relation to the fitness and evolutionary success of mutant strains.
Copyright © 2014. Published by Elsevier Ltd.
|Number of pages||8|
|Journal||Trends in Microbiology|
|Early online date||16 May 2014|
|Publication status||Published - 1 Aug 2014|