Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans: a randomised, controlled, double-masked, cross-over intervention study

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Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans : a randomised, controlled, double-masked, cross-over intervention study. / Rendeiro, Catarina; Dong, Honglin; Saunders, Caroline; Harkness, Laura; Blaze, Melvin; Hou, Yanpeng; Belanger, Ronald L; Corona, Giulia; Lovegrove, Julie A; Spencer, Jeremy P E.

In: The British journal of nutrition, Vol. 116, No. 12, 09.01.2017, p. 1999-2010.

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Rendeiro, Catarina ; Dong, Honglin ; Saunders, Caroline ; Harkness, Laura ; Blaze, Melvin ; Hou, Yanpeng ; Belanger, Ronald L ; Corona, Giulia ; Lovegrove, Julie A ; Spencer, Jeremy P E. / Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans : a randomised, controlled, double-masked, cross-over intervention study. In: The British journal of nutrition. 2017 ; Vol. 116, No. 12. pp. 1999-2010.

Bibtex

@article{d697e5b67e4e404f80f91ce1431d477d,
title = "Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans: a randomised, controlled, double-masked, cross-over intervention study",
abstract = "Specific flavonoid-rich foods/beverages are reported to exert positive effects on vascular function; however, data relating to effects in the postprandial state are limited. The present study investigated the postprandial, time-dependent (0-7 h) impact of citrus flavanone intake on vascular function. An acute, randomised, controlled, double-masked, cross-over intervention study was conducted by including middle-aged healthy men (30-65 years, n 28) to assess the impact of flavanone intake (orange juice: 128·9 mg; flavanone-rich orange juice: 272·1 mg; homogenised whole orange: 452·8 mg; isoenergetic control: 0 mg flavanones) on postprandial (double meal delivering a total of 81 g of fat) endothelial function. Endothelial function was assessed by flow-mediated dilatation (FMD) of the brachial artery at 0, 2, 5 and 7 h. Plasma levels of naringenin/hesperetin metabolites (sulphates and glucuronides) and nitric oxide species were also measured. All flavanone interventions were effective at attenuating transient impairments in FMD induced by the double meal (7 h post intake; P<0·05), but no dose-response effects were observed. The effects on FMD coincided with the peak of naringenin/hesperetin metabolites in circulation (7 h) and sustained levels of plasma nitrite. In summary, citrus flavanones are effective at counteracting the negative impact of a sequential double meal on human vascular function, potentially through the actions of flavanone metabolites on nitric oxide.",
keywords = "Adult, Biomarkers, Brachial Artery, Breakfast, Cardiovascular Diseases, Citrus, Cross-Over Studies, Diet, High-Fat, Dilatation, Pathologic, Double-Blind Method, Endothelium, Vascular, England, Flavanones, Fruit and Vegetable Juices, Humans, Lunch, Male, Middle Aged, Nitric Oxide, Patient Dropouts, Postprandial Period, Risk, Ultrasonography, Clinical Trial, Journal Article, Randomized Controlled Trial",
author = "Catarina Rendeiro and Honglin Dong and Caroline Saunders and Laura Harkness and Melvin Blaze and Yanpeng Hou and Belanger, {Ronald L} and Giulia Corona and Lovegrove, {Julie A} and Spencer, {Jeremy P E}",
year = "2017",
month = jan,
day = "9",
doi = "10.1017/S0007114516004219",
language = "English",
volume = "116",
pages = "1999--2010",
journal = "The British journal of nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "12",

}

RIS

TY - JOUR

T1 - Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans

T2 - a randomised, controlled, double-masked, cross-over intervention study

AU - Rendeiro, Catarina

AU - Dong, Honglin

AU - Saunders, Caroline

AU - Harkness, Laura

AU - Blaze, Melvin

AU - Hou, Yanpeng

AU - Belanger, Ronald L

AU - Corona, Giulia

AU - Lovegrove, Julie A

AU - Spencer, Jeremy P E

PY - 2017/1/9

Y1 - 2017/1/9

N2 - Specific flavonoid-rich foods/beverages are reported to exert positive effects on vascular function; however, data relating to effects in the postprandial state are limited. The present study investigated the postprandial, time-dependent (0-7 h) impact of citrus flavanone intake on vascular function. An acute, randomised, controlled, double-masked, cross-over intervention study was conducted by including middle-aged healthy men (30-65 years, n 28) to assess the impact of flavanone intake (orange juice: 128·9 mg; flavanone-rich orange juice: 272·1 mg; homogenised whole orange: 452·8 mg; isoenergetic control: 0 mg flavanones) on postprandial (double meal delivering a total of 81 g of fat) endothelial function. Endothelial function was assessed by flow-mediated dilatation (FMD) of the brachial artery at 0, 2, 5 and 7 h. Plasma levels of naringenin/hesperetin metabolites (sulphates and glucuronides) and nitric oxide species were also measured. All flavanone interventions were effective at attenuating transient impairments in FMD induced by the double meal (7 h post intake; P<0·05), but no dose-response effects were observed. The effects on FMD coincided with the peak of naringenin/hesperetin metabolites in circulation (7 h) and sustained levels of plasma nitrite. In summary, citrus flavanones are effective at counteracting the negative impact of a sequential double meal on human vascular function, potentially through the actions of flavanone metabolites on nitric oxide.

AB - Specific flavonoid-rich foods/beverages are reported to exert positive effects on vascular function; however, data relating to effects in the postprandial state are limited. The present study investigated the postprandial, time-dependent (0-7 h) impact of citrus flavanone intake on vascular function. An acute, randomised, controlled, double-masked, cross-over intervention study was conducted by including middle-aged healthy men (30-65 years, n 28) to assess the impact of flavanone intake (orange juice: 128·9 mg; flavanone-rich orange juice: 272·1 mg; homogenised whole orange: 452·8 mg; isoenergetic control: 0 mg flavanones) on postprandial (double meal delivering a total of 81 g of fat) endothelial function. Endothelial function was assessed by flow-mediated dilatation (FMD) of the brachial artery at 0, 2, 5 and 7 h. Plasma levels of naringenin/hesperetin metabolites (sulphates and glucuronides) and nitric oxide species were also measured. All flavanone interventions were effective at attenuating transient impairments in FMD induced by the double meal (7 h post intake; P<0·05), but no dose-response effects were observed. The effects on FMD coincided with the peak of naringenin/hesperetin metabolites in circulation (7 h) and sustained levels of plasma nitrite. In summary, citrus flavanones are effective at counteracting the negative impact of a sequential double meal on human vascular function, potentially through the actions of flavanone metabolites on nitric oxide.

KW - Adult

KW - Biomarkers

KW - Brachial Artery

KW - Breakfast

KW - Cardiovascular Diseases

KW - Citrus

KW - Cross-Over Studies

KW - Diet, High-Fat

KW - Dilatation, Pathologic

KW - Double-Blind Method

KW - Endothelium, Vascular

KW - England

KW - Flavanones

KW - Fruit and Vegetable Juices

KW - Humans

KW - Lunch

KW - Male

KW - Middle Aged

KW - Nitric Oxide

KW - Patient Dropouts

KW - Postprandial Period

KW - Risk

KW - Ultrasonography

KW - Clinical Trial

KW - Journal Article

KW - Randomized Controlled Trial

U2 - 10.1017/S0007114516004219

DO - 10.1017/S0007114516004219

M3 - Article

C2 - 28065188

VL - 116

SP - 1999

EP - 2010

JO - The British journal of nutrition

JF - The British journal of nutrition

SN - 0007-1145

IS - 12

ER -