Fitness of Escherichia coli strains carrying expressed and partially silent IncN and IncP1 plasmids

Research output: Contribution to journalArticlepeer-review


  • Bruce Humphrey
  • Nicholas R Thomson
  • Karen Brooks
  • Mandy Sanders
  • Anne A Delsol
  • John M Roe
  • Peter M Bennett
  • Virve I Enne

Colleges, School and Institutes


Understanding the survival of resistance plasmids in the absence of selective pressure for the antibiotic resistance genes they carry is important for assessing the value of interventions to combat resistant bacteria. Here, several poorly explored questions regarding the fitness impact of IncP1 and IncN broad host range plasmids on their bacterial hosts are examined; namely, whether related plasmids have similar fitness impacts, whether this varies according to host genetic background, and what effect antimicrobial resistance gene silencing has on fitness.


Original languageEnglish
Article number53
JournalBMC Microbiology
Publication statusPublished - 4 Apr 2012