Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration

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Firearms-related skeletal muscle trauma : pathophysiology and novel approaches for regeneration. / Moriscot, Anselmo; Miyabara, Elen H; Langeani, Bruno; Belli, Antonio; Egginton, Stuart; Bowen, T Scott.

In: npj Regenerative Medicine, Vol. 6, No. 1, 17, 12.2021.

Research output: Contribution to journalReview articlepeer-review

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Moriscot, Anselmo ; Miyabara, Elen H ; Langeani, Bruno ; Belli, Antonio ; Egginton, Stuart ; Bowen, T Scott. / Firearms-related skeletal muscle trauma : pathophysiology and novel approaches for regeneration. In: npj Regenerative Medicine. 2021 ; Vol. 6, No. 1.

Bibtex

@article{02ffe41c83d34246915d16da211eea5f,
title = "Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration",
abstract = "One major cause of traumatic injury is firearm-related wounds (i.e., ballistic trauma), common in both civilian and military populations, which is increasing in prevalence and has serious long-term health and socioeconomic consequences worldwide. Common primary injuries of ballistic trauma include soft-tissue damage and loss, haemorrhage, bone fracture, and pain. The majority of injuries are of musculoskeletal origin and located in the extremities, such that skeletal muscle offers a major therapeutic target to aid recovery and return to normal daily activities. However, the underlying pathophysiology of skeletal muscle ballistic trauma remains poorly understood, with limited evidence-based treatment options. As such, this review will address the topic of firearm-related skeletal muscle injury and regeneration. We first introduce trauma ballistics and the immediate injury of skeletal muscle, followed by detailed coverage of the underlying biological mechanisms involved in regulating skeletal muscle dysfunction following injury, with a specific focus on the processes of muscle regeneration, muscle wasting and vascular impairments. Finally, we evaluate novel approaches for minimising muscle damage and enhancing muscle regeneration after ballistic trauma, which may have important relevance for primary care in victims of violence.",
author = "Anselmo Moriscot and Miyabara, {Elen H} and Bruno Langeani and Antonio Belli and Stuart Egginton and Bowen, {T Scott}",
year = "2021",
month = mar,
day = "26",
doi = "10.1038/s41536-021-00127-1",
language = "English",
volume = "6",
journal = "npj Regenerative Medicine",
issn = "2057-3995",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Firearms-related skeletal muscle trauma

T2 - pathophysiology and novel approaches for regeneration

AU - Moriscot, Anselmo

AU - Miyabara, Elen H

AU - Langeani, Bruno

AU - Belli, Antonio

AU - Egginton, Stuart

AU - Bowen, T Scott

PY - 2021/3/26

Y1 - 2021/3/26

N2 - One major cause of traumatic injury is firearm-related wounds (i.e., ballistic trauma), common in both civilian and military populations, which is increasing in prevalence and has serious long-term health and socioeconomic consequences worldwide. Common primary injuries of ballistic trauma include soft-tissue damage and loss, haemorrhage, bone fracture, and pain. The majority of injuries are of musculoskeletal origin and located in the extremities, such that skeletal muscle offers a major therapeutic target to aid recovery and return to normal daily activities. However, the underlying pathophysiology of skeletal muscle ballistic trauma remains poorly understood, with limited evidence-based treatment options. As such, this review will address the topic of firearm-related skeletal muscle injury and regeneration. We first introduce trauma ballistics and the immediate injury of skeletal muscle, followed by detailed coverage of the underlying biological mechanisms involved in regulating skeletal muscle dysfunction following injury, with a specific focus on the processes of muscle regeneration, muscle wasting and vascular impairments. Finally, we evaluate novel approaches for minimising muscle damage and enhancing muscle regeneration after ballistic trauma, which may have important relevance for primary care in victims of violence.

AB - One major cause of traumatic injury is firearm-related wounds (i.e., ballistic trauma), common in both civilian and military populations, which is increasing in prevalence and has serious long-term health and socioeconomic consequences worldwide. Common primary injuries of ballistic trauma include soft-tissue damage and loss, haemorrhage, bone fracture, and pain. The majority of injuries are of musculoskeletal origin and located in the extremities, such that skeletal muscle offers a major therapeutic target to aid recovery and return to normal daily activities. However, the underlying pathophysiology of skeletal muscle ballistic trauma remains poorly understood, with limited evidence-based treatment options. As such, this review will address the topic of firearm-related skeletal muscle injury and regeneration. We first introduce trauma ballistics and the immediate injury of skeletal muscle, followed by detailed coverage of the underlying biological mechanisms involved in regulating skeletal muscle dysfunction following injury, with a specific focus on the processes of muscle regeneration, muscle wasting and vascular impairments. Finally, we evaluate novel approaches for minimising muscle damage and enhancing muscle regeneration after ballistic trauma, which may have important relevance for primary care in victims of violence.

U2 - 10.1038/s41536-021-00127-1

DO - 10.1038/s41536-021-00127-1

M3 - Review article

C2 - 33772028

VL - 6

JO - npj Regenerative Medicine

JF - npj Regenerative Medicine

SN - 2057-3995

IS - 1

M1 - 17

ER -