Fine needle aspiration and medulla

Research output: Contribution to journalArticlepeer-review


  • Garth Essig
  • Kyle Porter
  • David Schneider
  • Arpaia Debora
  • Susan Lindsey
  • Giulia Busonero
  • Daniel Fineberg
  • Barbara Fruci
  • Johannes Smit
  • Johannes Meijer
  • Leonidas Duntas
  • Giuseppe Costante
  • Sebastiano Filetti
  • Rebecca Sippel
  • Bernadette Biondi
  • Duncan Topliss
  • Furio Pacini
  • Rui MacIel
  • Patrick Walz
  • Richard Kloos

External organisations

  • Ohio State University
  • University of Wisconsin School of Medicine and Public Health
  • Universita degli Studi di Napoli Federico II
  • Departamento de Ciências Farmacêuticas
  • University of Siena
  • Monash University
  • University of Catanzaro Magna Græcia
  • Radboud University Medical Centre
  • Albert Schweitzer Hospital, Dordrecht
  • University of Athens
  • Institut Jules Bordet
  • Università di Roma la Sapienza
  • Ohio State University College of Medicine
  • Veracyte Inc


Objectives: To evaluate the diagnostic accuracy of fine-needle aspiration biopsy (FNAB) to preoperatively diagnose medullary thyroid cancer (MTC) among multiple international centers and evaluate how the cytological diagnosis alone could impact patient management.Methods: We performed a retrospective chart review of sporadic MTC (sMTC) patients from 12 institutions over the last 29 years. FNAB cytology results were compared to final pathologic diagnoses to calculate FNAB sensitivity. To evaluate the impact of cytology sensitivity for MTC according to current practice and to avoid confounding results by local treatment protocols, changes in treatment patterns over time, and the influence of ancillary findings (e.g., serum calcitonin), therapeutic interventions based on FNAB cytology alone were projected into 1 of 4 treatment categories: total thyroidectomy (TT) and central neck dissection (CND), TT without CND, diagnostic hemithyroidectomy, or observation.Results: A total of 313 patients from 4 continents and 7 countries were included, 245 of whom underwent FNAB. FNAB cytology revealed MTC in 43.7% and possible MTC in an additional 2.4%. A total of 113 (46.1%) patients with surgical pathology revealing sMTC had FNAB findings that supported TT with CND, while 37 (15.1%) supported TT alone. In the remaining cases, diagnostic hemithyroidectomy and observation were projected in 32.7% and 6.1%, respectively.Conclusion: FNAB is an important diagnostic tool in the evaluation of thyroid nodules, but the low sensitivity of cytological evaluation alone in sMTC limits its ability to command an optimal preoperative evaluation and initial surgery in over half of affected patients.


Original languageEnglish
Pages (from-to)920-927
Number of pages8
JournalEndocrine Practice
Issue number6
Publication statusPublished - 1 Nov 2013