Fibroblasts as immune regulators in infection, inflammation and cancer

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Fibroblasts as immune regulators in infection, inflammation and cancer. / Davidson, Sarah; Coles, Mark; Thomas, Tom; Kollias, George; Ludewig, Burkhard; Turley, Shannon; Brenner, Michael; Buckley, Christopher D.

In: Nature Reviews Immunology, 28.04.2021.

Research output: Contribution to journalReview articlepeer-review

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Davidson, Sarah ; Coles, Mark ; Thomas, Tom ; Kollias, George ; Ludewig, Burkhard ; Turley, Shannon ; Brenner, Michael ; Buckley, Christopher D. / Fibroblasts as immune regulators in infection, inflammation and cancer. In: Nature Reviews Immunology. 2021.

Bibtex

@article{90b3248d4cf24a11a8567ad1f5c876ca,
title = "Fibroblasts as immune regulators in infection, inflammation and cancer",
abstract = "In chronic infection, inflammation and cancer, the tissue microenvironment controls how local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in regulating activation or suppression of an immune response. Fibroblasts are heterogeneous cells, encompassing functionally distinct populations, the phenotypes of which differ according to their tissue of origin and type of inciting disease. Their immunological properties are also diverse, ranging from the maintenance of a potent inflammatory environment in chronic inflammation to promoting immunosuppression in malignancy, and encapsulating and incarcerating infectious agents within tissues. In this Review, we compare the mechanisms by which fibroblasts control local immune responses, as well as the factors regulating their inflammatory and suppressive profiles, in different tissues and pathological settings. This cross-disease perspective highlights the importance of tissue context in determining fibroblast–immune cell interactions, as well as potential therapeutic avenues to exploit this knowledge for the benefit of patients with chronic infection, inflammation and cancer.",
author = "Sarah Davidson and Mark Coles and Tom Thomas and George Kollias and Burkhard Ludewig and Shannon Turley and Michael Brenner and Buckley, {Christopher D.}",
year = "2021",
month = apr,
day = "28",
doi = "10.1038/s41577-021-00540-z",
language = "English",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Fibroblasts as immune regulators in infection, inflammation and cancer

AU - Davidson, Sarah

AU - Coles, Mark

AU - Thomas, Tom

AU - Kollias, George

AU - Ludewig, Burkhard

AU - Turley, Shannon

AU - Brenner, Michael

AU - Buckley, Christopher D.

PY - 2021/4/28

Y1 - 2021/4/28

N2 - In chronic infection, inflammation and cancer, the tissue microenvironment controls how local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in regulating activation or suppression of an immune response. Fibroblasts are heterogeneous cells, encompassing functionally distinct populations, the phenotypes of which differ according to their tissue of origin and type of inciting disease. Their immunological properties are also diverse, ranging from the maintenance of a potent inflammatory environment in chronic inflammation to promoting immunosuppression in malignancy, and encapsulating and incarcerating infectious agents within tissues. In this Review, we compare the mechanisms by which fibroblasts control local immune responses, as well as the factors regulating their inflammatory and suppressive profiles, in different tissues and pathological settings. This cross-disease perspective highlights the importance of tissue context in determining fibroblast–immune cell interactions, as well as potential therapeutic avenues to exploit this knowledge for the benefit of patients with chronic infection, inflammation and cancer.

AB - In chronic infection, inflammation and cancer, the tissue microenvironment controls how local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in regulating activation or suppression of an immune response. Fibroblasts are heterogeneous cells, encompassing functionally distinct populations, the phenotypes of which differ according to their tissue of origin and type of inciting disease. Their immunological properties are also diverse, ranging from the maintenance of a potent inflammatory environment in chronic inflammation to promoting immunosuppression in malignancy, and encapsulating and incarcerating infectious agents within tissues. In this Review, we compare the mechanisms by which fibroblasts control local immune responses, as well as the factors regulating their inflammatory and suppressive profiles, in different tissues and pathological settings. This cross-disease perspective highlights the importance of tissue context in determining fibroblast–immune cell interactions, as well as potential therapeutic avenues to exploit this knowledge for the benefit of patients with chronic infection, inflammation and cancer.

U2 - 10.1038/s41577-021-00540-z

DO - 10.1038/s41577-021-00540-z

M3 - Review article

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

SN - 1474-1733

ER -