Fibrates and medroxyprogesterone acetate induce apoptosis of primary Burkitt’s lymphoma cells and cell lines: potential for applying old drugs to a new disease

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Fibrates and medroxyprogesterone acetate induce apoptosis of primary Burkitt’s lymphoma cells and cell lines: potential for applying old drugs to a new disease. / Fenton, S; Luong, Q; [No Value], [No Value]; Mustard, K; Pound, JD; Desmond, J; Gordon, John; Drayson, Mark; Bunce, Christopher.

In: Leukemia, Vol. 17, No. 3, 01.03.2003, p. 568-575.

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@article{e35f4f4342f344b798636094674664b1,
title = "Fibrates and medroxyprogesterone acetate induce apoptosis of primary Burkitt{\textquoteright}s lymphoma cells and cell lines: potential for applying old drugs to a new disease",
abstract = "Current therapies for Burkitt's lymphoma (BL) utilise combined cytotoxic chemotherapy, but these treatments are not always available in areas where the disease is endemic and are also markedly less successful in AIDS-related BL. Therefore, additional therapies are urgently required. We demonstrate here that combined fibrates and MPA exert powerful, antiproliferative actions against well-characterised Daudi, Raji and L3055 BL cell lines and primary BL cells. Detailed studies in L3055 demonstrated that this activity was mediated by induced apoptosis and confirmed by observations that overexpression of the antiapoptotic genes bcl-2 or bcl-X-L conferred significant protection against the drugs. Importantly, since fibrates and MPA are inexpensive and stable with minimal-associated toxicities, we suggest that these drugs should be considered as adjuncts to currently available treatments for BL in endemic and AIDS-related disease.",
keywords = "fibrates, Burkitt's lymphoma, combination therapy, medroxyprogesterone acetate, apoptosis",
author = "S Fenton and Q Luong and {[No Value]}, {[No Value]} and K Mustard and JD Pound and J Desmond and John Gordon and Mark Drayson and Christopher Bunce",
year = "2003",
month = mar,
day = "1",
doi = "10.1038/sj.leu.2402843",
language = "English",
volume = "17",
pages = "568--575",
journal = "Leukemia",
issn = "0887-6924",
publisher = "Nature Publishing Group",
number = "3",

}

RIS

TY - JOUR

T1 - Fibrates and medroxyprogesterone acetate induce apoptosis of primary Burkitt’s lymphoma cells and cell lines: potential for applying old drugs to a new disease

AU - Fenton, S

AU - Luong, Q

AU - [No Value], [No Value]

AU - Mustard, K

AU - Pound, JD

AU - Desmond, J

AU - Gordon, John

AU - Drayson, Mark

AU - Bunce, Christopher

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Current therapies for Burkitt's lymphoma (BL) utilise combined cytotoxic chemotherapy, but these treatments are not always available in areas where the disease is endemic and are also markedly less successful in AIDS-related BL. Therefore, additional therapies are urgently required. We demonstrate here that combined fibrates and MPA exert powerful, antiproliferative actions against well-characterised Daudi, Raji and L3055 BL cell lines and primary BL cells. Detailed studies in L3055 demonstrated that this activity was mediated by induced apoptosis and confirmed by observations that overexpression of the antiapoptotic genes bcl-2 or bcl-X-L conferred significant protection against the drugs. Importantly, since fibrates and MPA are inexpensive and stable with minimal-associated toxicities, we suggest that these drugs should be considered as adjuncts to currently available treatments for BL in endemic and AIDS-related disease.

AB - Current therapies for Burkitt's lymphoma (BL) utilise combined cytotoxic chemotherapy, but these treatments are not always available in areas where the disease is endemic and are also markedly less successful in AIDS-related BL. Therefore, additional therapies are urgently required. We demonstrate here that combined fibrates and MPA exert powerful, antiproliferative actions against well-characterised Daudi, Raji and L3055 BL cell lines and primary BL cells. Detailed studies in L3055 demonstrated that this activity was mediated by induced apoptosis and confirmed by observations that overexpression of the antiapoptotic genes bcl-2 or bcl-X-L conferred significant protection against the drugs. Importantly, since fibrates and MPA are inexpensive and stable with minimal-associated toxicities, we suggest that these drugs should be considered as adjuncts to currently available treatments for BL in endemic and AIDS-related disease.

KW - fibrates

KW - Burkitt's lymphoma

KW - combination therapy

KW - medroxyprogesterone acetate

KW - apoptosis

UR - http://www.scopus.com/inward/record.url?scp=0345701970&partnerID=8YFLogxK

U2 - 10.1038/sj.leu.2402843

DO - 10.1038/sj.leu.2402843

M3 - Article

C2 - 12646946

VL - 17

SP - 568

EP - 575

JO - Leukemia

JF - Leukemia

SN - 0887-6924

IS - 3

ER -