Feedback-controlled release of alendronate from composite microparticles

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Feedback-controlled release of alendronate from composite microparticles. / Matrali, Sofia S.H.; Ghag, Anita K.

In: Journal of Functional Biomaterials, Vol. 11, No. 3, 46, 01.07.2020.

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@article{47e0b1bf302140db9f75cb24b01cd371,
title = "Feedback-controlled release of alendronate from composite microparticles",
abstract = "Extended bone fractures or fractures coexisting with bone disorders can lead to non-unions where surgical intervention is required. Composite drug delivery systems are being used increasingly more in order to treat such defects locally. Alendronate (ALD), a bisphosphonate extensively used in clinical practice to treat conditions, such as osteoporosis, has been shown to assist bone fracture healing through its antiresorptive capacity. This study reports the development of a polymeric composite system for the in situ delivery of ALD, which possesses enhanced encapsulation efficiency (EE%) and demonstrates controlled release over a 70-day period. ALD and calcium phosphate (CaP) were incorporated within poly (lactic-co-glycolic acid) (PLGA) microspheres, giving rise to a 70% increase in EE% compared to a control system. Finally, a preliminary toxicological evaluation demonstrated a positive effect of the system on pre-osteoblastic cells over 72 h.",
keywords = "Biodegradable, Bisphosphonate, Bone, Composite, Controlled release, Drug delivery",
author = "Matrali, {Sofia S.H.} and Ghag, {Anita K.}",
year = "2020",
month = jul,
day = "1",
doi = "10.3390/JFB11030046",
language = "English",
volume = "11",
journal = "Journal of Functional Biomaterials",
issn = "2079-4983",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

RIS

TY - JOUR

T1 - Feedback-controlled release of alendronate from composite microparticles

AU - Matrali, Sofia S.H.

AU - Ghag, Anita K.

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Extended bone fractures or fractures coexisting with bone disorders can lead to non-unions where surgical intervention is required. Composite drug delivery systems are being used increasingly more in order to treat such defects locally. Alendronate (ALD), a bisphosphonate extensively used in clinical practice to treat conditions, such as osteoporosis, has been shown to assist bone fracture healing through its antiresorptive capacity. This study reports the development of a polymeric composite system for the in situ delivery of ALD, which possesses enhanced encapsulation efficiency (EE%) and demonstrates controlled release over a 70-day period. ALD and calcium phosphate (CaP) were incorporated within poly (lactic-co-glycolic acid) (PLGA) microspheres, giving rise to a 70% increase in EE% compared to a control system. Finally, a preliminary toxicological evaluation demonstrated a positive effect of the system on pre-osteoblastic cells over 72 h.

AB - Extended bone fractures or fractures coexisting with bone disorders can lead to non-unions where surgical intervention is required. Composite drug delivery systems are being used increasingly more in order to treat such defects locally. Alendronate (ALD), a bisphosphonate extensively used in clinical practice to treat conditions, such as osteoporosis, has been shown to assist bone fracture healing through its antiresorptive capacity. This study reports the development of a polymeric composite system for the in situ delivery of ALD, which possesses enhanced encapsulation efficiency (EE%) and demonstrates controlled release over a 70-day period. ALD and calcium phosphate (CaP) were incorporated within poly (lactic-co-glycolic acid) (PLGA) microspheres, giving rise to a 70% increase in EE% compared to a control system. Finally, a preliminary toxicological evaluation demonstrated a positive effect of the system on pre-osteoblastic cells over 72 h.

KW - Biodegradable

KW - Bisphosphonate

KW - Bone

KW - Composite

KW - Controlled release

KW - Drug delivery

UR - http://www.scopus.com/inward/record.url?scp=85090386516&partnerID=8YFLogxK

U2 - 10.3390/JFB11030046

DO - 10.3390/JFB11030046

M3 - Article

C2 - 32630317

AN - SCOPUS:85090386516

VL - 11

JO - Journal of Functional Biomaterials

JF - Journal of Functional Biomaterials

SN - 2079-4983

IS - 3

M1 - 46

ER -