Features and prognostic utility of biopsy in oral squamous cell carcinoma

Jagtar Dhanda; Nugdeep Uppal; Harpreet Chowlia; Neil Opie; Laith Al-Qamachi; Devesh Shelat; Adil Aslam; Arie Yuffa; Timothy Martin; Janet Risk; Asterios Triantafyllou; Richard Shaw; Satyesh Parmar; Hisham Mehanna

doi:10.1002/hed.24335

Features and prognostic utility of biopsy in oral squamous cell carcinoma

Jagtar Dhanda, Nugdeep Uppal, Harpreet Chowlia, Neil Opie, Laith Al-Qamachi, Devesh Shelat, Adil Aslam, Arie Yuffa, Timothy Martin, Janet Risk, Asterios Triantafyllou, Richard Shaw, Satyesh Parmar, Hisham Mehanna

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

BACKGROUND: Traditional approaches in oral squamous cell carcinoma (OSCC) management utilize biopsy tissue for diagnostic purposes only. Adverse prognostic features, such as the tumor depth, are usually determined from final resection specimens, but are seldom studied in biopsy tissue.

METHODS: A preliminary study of 139 consecutive biopsies compared biopsy size with T classification, tumor site, and operator grade, and biopsy tumor depth with the true tumor depth.

RESULTS: This study demonstrated that biopsy size is independent of T classification (p = .44), subsite (p = .86), and operator grade (p = .10). The biopsy tumor depth significantly underrepresented true tumor depth (2.5 mm, 95% confidence interval [CI] = 2.4-2.9 vs 8.2 mm, 95% CI = 6.5-9.9; p < .001), confirming the limited prognostic utility of biopsies in OSCC.

CONCLUSION: A future clinical trial will compare the routine biopsy technique with standardized deeper biopsy techniques using punch biopsy to sample invasive fronts and investigate opportunities for up-front staging using a combination of histological features and epithelial and stromal molecular biomarkers in OSCC. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.

Original language	English
Pages (from-to)	E1857-E1862
Number of pages	6
Journal	Head & Neck
Volume	38
Issue number	S1
Early online date	24 Dec 2015
DOIs	https://doi.org/10.1002/hed.24335
Publication status	Published - Apr 2016

Keywords

biopsy
features
prognostic
oral
cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.1002/hed.24335Licence: None: All rights reserved

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@article{00c5832df44a423e8f24ffd9bb3cd632,

title = "Features and prognostic utility of biopsy in oral squamous cell carcinoma",

abstract = "BACKGROUND: Traditional approaches in oral squamous cell carcinoma (OSCC) management utilize biopsy tissue for diagnostic purposes only. Adverse prognostic features, such as the tumor depth, are usually determined from final resection specimens, but are seldom studied in biopsy tissue.METHODS: A preliminary study of 139 consecutive biopsies compared biopsy size with T classification, tumor site, and operator grade, and biopsy tumor depth with the true tumor depth.RESULTS: This study demonstrated that biopsy size is independent of T classification (p = .44), subsite (p = .86), and operator grade (p = .10). The biopsy tumor depth significantly underrepresented true tumor depth (2.5 mm, 95% confidence interval [CI] = 2.4-2.9 vs 8.2 mm, 95% CI = 6.5-9.9; p < .001), confirming the limited prognostic utility of biopsies in OSCC.CONCLUSION: A future clinical trial will compare the routine biopsy technique with standardized deeper biopsy techniques using punch biopsy to sample invasive fronts and investigate opportunities for up-front staging using a combination of histological features and epithelial and stromal molecular biomarkers in OSCC. {\textcopyright} 2015 Wiley Periodicals, Inc. Head Neck, 2015.",

keywords = "biopsy, features, prognostic, oral, cancer",

author = "Jagtar Dhanda and Nugdeep Uppal and Harpreet Chowlia and Neil Opie and Laith Al-Qamachi and Devesh Shelat and Adil Aslam and Arie Yuffa and Timothy Martin and Janet Risk and Asterios Triantafyllou and Richard Shaw and Satyesh Parmar and Hisham Mehanna",

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year = "2016",

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doi = "10.1002/hed.24335",

language = "English",

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TY - JOUR

T1 - Features and prognostic utility of biopsy in oral squamous cell carcinoma

AU - Dhanda, Jagtar

AU - Uppal, Nugdeep

AU - Chowlia, Harpreet

AU - Opie, Neil

AU - Al-Qamachi, Laith

AU - Shelat, Devesh

AU - Aslam, Adil

AU - Yuffa, Arie

AU - Martin, Timothy

AU - Risk, Janet

AU - Triantafyllou, Asterios

AU - Shaw, Richard

AU - Parmar, Satyesh

AU - Mehanna, Hisham

PY - 2016/4

Y1 - 2016/4

N2 - BACKGROUND: Traditional approaches in oral squamous cell carcinoma (OSCC) management utilize biopsy tissue for diagnostic purposes only. Adverse prognostic features, such as the tumor depth, are usually determined from final resection specimens, but are seldom studied in biopsy tissue.METHODS: A preliminary study of 139 consecutive biopsies compared biopsy size with T classification, tumor site, and operator grade, and biopsy tumor depth with the true tumor depth.RESULTS: This study demonstrated that biopsy size is independent of T classification (p = .44), subsite (p = .86), and operator grade (p = .10). The biopsy tumor depth significantly underrepresented true tumor depth (2.5 mm, 95% confidence interval [CI] = 2.4-2.9 vs 8.2 mm, 95% CI = 6.5-9.9; p < .001), confirming the limited prognostic utility of biopsies in OSCC.CONCLUSION: A future clinical trial will compare the routine biopsy technique with standardized deeper biopsy techniques using punch biopsy to sample invasive fronts and investigate opportunities for up-front staging using a combination of histological features and epithelial and stromal molecular biomarkers in OSCC. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.

AB - BACKGROUND: Traditional approaches in oral squamous cell carcinoma (OSCC) management utilize biopsy tissue for diagnostic purposes only. Adverse prognostic features, such as the tumor depth, are usually determined from final resection specimens, but are seldom studied in biopsy tissue.METHODS: A preliminary study of 139 consecutive biopsies compared biopsy size with T classification, tumor site, and operator grade, and biopsy tumor depth with the true tumor depth.RESULTS: This study demonstrated that biopsy size is independent of T classification (p = .44), subsite (p = .86), and operator grade (p = .10). The biopsy tumor depth significantly underrepresented true tumor depth (2.5 mm, 95% confidence interval [CI] = 2.4-2.9 vs 8.2 mm, 95% CI = 6.5-9.9; p < .001), confirming the limited prognostic utility of biopsies in OSCC.CONCLUSION: A future clinical trial will compare the routine biopsy technique with standardized deeper biopsy techniques using punch biopsy to sample invasive fronts and investigate opportunities for up-front staging using a combination of histological features and epithelial and stromal molecular biomarkers in OSCC. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.

KW - biopsy

KW - features

KW - prognostic

KW - oral

KW - cancer

U2 - 10.1002/hed.24335

DO - 10.1002/hed.24335

M3 - Article

C2 - 26705271

SN - 1043-3074

VL - 38

SP - E1857-E1862

JO - Head & Neck

JF - Head & Neck

IS - S1

ER -

Features and prognostic utility of biopsy in oral squamous cell carcinoma

Abstract

Keywords

UN SDGs

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