Feasibility of a bioadhesive drug delivery system targeted to oesophageal tissue

Research output: Contribution to journalArticle

Authors

  • M. Tang
  • P.W. Dettmar
  • F.C. Hampson
  • I.G. Jolliffe
  • D.Q.M. Craig

Colleges, School and Institutes

External organisations

  • Queen's University Belfast
  • Aston University
  • Reckitt Benckiser

Abstract

This contribution examines the feasibility of utilising an oesophageal-adhesive alginate layer to support model drug particles. Such a bioadhesive system offers the prospect of local drug delivery to the oesophagus, which in turn has applications in the treatment of conditions including gastro-oesophageal reflux disease and oesophageal cancer. Surface-modified (amine, carboxylate and sulfate) as well as neutral fluorescent beads were investigated as model drug particles. A fluorescence assay technique was utilised to quantify the extent and duration of adhesion of a fixed dose of these particles to excised porcine oesophageal tissue. Retention of the particles was investigated both from aqueous systems and within an adhesive alginate solution. After 30 min significantly higher adhesion of neutral beads was recorded from the alginate solution as compared to the aqueous suspension (n=6, P0.05).

Details

Original languageEnglish
Pages (from-to)295-298
Number of pages4
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume57
Issue number2
Publication statusPublished - 1 Mar 2004