Fate of the anthelmintic phenothiazine in man

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Fate of the anthelmintic phenothiazine in man. / Mitchell, SC; Kestell, P; Steventon, GB; Waring, Rosemary.

In: Xenobiotica, Vol. 32, No. 9, 01.09.2002, p. 771-782.

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Mitchell, SC, Kestell, P, Steventon, GB & Waring, R 2002, 'Fate of the anthelmintic phenothiazine in man', Xenobiotica, vol. 32, no. 9, pp. 771-782. https://doi.org/10.1080/00498250210143038

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Mitchell, SC ; Kestell, P ; Steventon, GB ; Waring, Rosemary. / Fate of the anthelmintic phenothiazine in man. In: Xenobiotica. 2002 ; Vol. 32, No. 9. pp. 771-782.

Bibtex

@article{50c3c23503bc4bdba5f3818c2417d1df,
title = "Fate of the anthelmintic phenothiazine in man",
abstract = "1. Radiolabelled [(35)S]-phenothiazine has been administered orally to two healthy adult male volunteers (6 mg kg(-1) body weight). Faeces were the major route of excretion of radioactivity (68%), the remainder being eliminated via the urine (32%) with an estimated urinary half-life (biphasic) of 6-16 h. Over the 5 days of the study a complete recovery of radioactivity was achieved. 2. From urinary data, it was shown that metabolism occurred via ring carbon oxidation to form phenothiazone and thionol and via ring sulphur oxidation to form phenothiazine sulphoxide. The majority of urinary material (92%) was present in the form of conjugates of phenothiazine and phenothiazone. Only unchanged phenothiazine was detected in the faeces. Phenothiazine sulphoxide was reduced to phenothiazine during incubation with faecal homogenates.",
author = "SC Mitchell and P Kestell and GB Steventon and Rosemary Waring",
year = "2002",
month = sep,
day = "1",
doi = "10.1080/00498250210143038",
language = "English",
volume = "32",
pages = "771--782",
journal = "Xenobiotica",
issn = "0049-8254",
publisher = "Taylor & Francis",
number = "9",

}

RIS

TY - JOUR

T1 - Fate of the anthelmintic phenothiazine in man

AU - Mitchell, SC

AU - Kestell, P

AU - Steventon, GB

AU - Waring, Rosemary

PY - 2002/9/1

Y1 - 2002/9/1

N2 - 1. Radiolabelled [(35)S]-phenothiazine has been administered orally to two healthy adult male volunteers (6 mg kg(-1) body weight). Faeces were the major route of excretion of radioactivity (68%), the remainder being eliminated via the urine (32%) with an estimated urinary half-life (biphasic) of 6-16 h. Over the 5 days of the study a complete recovery of radioactivity was achieved. 2. From urinary data, it was shown that metabolism occurred via ring carbon oxidation to form phenothiazone and thionol and via ring sulphur oxidation to form phenothiazine sulphoxide. The majority of urinary material (92%) was present in the form of conjugates of phenothiazine and phenothiazone. Only unchanged phenothiazine was detected in the faeces. Phenothiazine sulphoxide was reduced to phenothiazine during incubation with faecal homogenates.

AB - 1. Radiolabelled [(35)S]-phenothiazine has been administered orally to two healthy adult male volunteers (6 mg kg(-1) body weight). Faeces were the major route of excretion of radioactivity (68%), the remainder being eliminated via the urine (32%) with an estimated urinary half-life (biphasic) of 6-16 h. Over the 5 days of the study a complete recovery of radioactivity was achieved. 2. From urinary data, it was shown that metabolism occurred via ring carbon oxidation to form phenothiazone and thionol and via ring sulphur oxidation to form phenothiazine sulphoxide. The majority of urinary material (92%) was present in the form of conjugates of phenothiazine and phenothiazone. Only unchanged phenothiazine was detected in the faeces. Phenothiazine sulphoxide was reduced to phenothiazine during incubation with faecal homogenates.

UR - http://www.scopus.com/inward/record.url?scp=0036745834&partnerID=8YFLogxK

U2 - 10.1080/00498250210143038

DO - 10.1080/00498250210143038

M3 - Article

C2 - 12396274

VL - 32

SP - 771

EP - 782

JO - Xenobiotica

JF - Xenobiotica

SN - 0049-8254

IS - 9

ER -