Fatal attraction : how bacterial adhesins affect host signaling and what we can learn from them

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Fatal attraction : how bacterial adhesins affect host signaling and what we can learn from them. / Stones, Daniel H; Krachler, Anne-Marie.

In: International Journal of Molecular Sciences, Vol. 16, No. 2, 23.01.2015, p. 2626-2640.

Research output: Contribution to journalArticlepeer-review

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@article{e8036fdd9dae4cbe9ad47801543ae692,
title = "Fatal attraction : how bacterial adhesins affect host signaling and what we can learn from them",
abstract = "The ability of bacterial species to colonize and infect host organisms is critically dependent upon their capacity to adhere to cellular surfaces of the host. Adherence to cell surfaces is known to be essential for the activation and delivery of certain virulence factors, but can also directly affect host cell signaling to aid bacterial spread and survival. In this review we will discuss the recent advances in the field of bacterial adhesion, how we are beginning to unravel the effects adhesins have on host cell signaling, and how these changes aid the bacteria in terms of their survival and evasion of immune responses. Finally, we will highlight how the exploitation of bacterial adhesins may provide new therapeutic avenues for the treatment of a wide range of bacterial infections.",
keywords = "adhesion, adhesin, cell-signaling, host–pathogen interaction, bacterial attachment, anti-adhesion therapy",
author = "Stones, {Daniel H} and Anne-Marie Krachler",
year = "2015",
month = jan,
day = "23",
doi = "10.3390/ijms16022626",
language = "English",
volume = "16",
pages = "2626--2640",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI",
number = "2",

}

RIS

TY - JOUR

T1 - Fatal attraction : how bacterial adhesins affect host signaling and what we can learn from them

AU - Stones, Daniel H

AU - Krachler, Anne-Marie

PY - 2015/1/23

Y1 - 2015/1/23

N2 - The ability of bacterial species to colonize and infect host organisms is critically dependent upon their capacity to adhere to cellular surfaces of the host. Adherence to cell surfaces is known to be essential for the activation and delivery of certain virulence factors, but can also directly affect host cell signaling to aid bacterial spread and survival. In this review we will discuss the recent advances in the field of bacterial adhesion, how we are beginning to unravel the effects adhesins have on host cell signaling, and how these changes aid the bacteria in terms of their survival and evasion of immune responses. Finally, we will highlight how the exploitation of bacterial adhesins may provide new therapeutic avenues for the treatment of a wide range of bacterial infections.

AB - The ability of bacterial species to colonize and infect host organisms is critically dependent upon their capacity to adhere to cellular surfaces of the host. Adherence to cell surfaces is known to be essential for the activation and delivery of certain virulence factors, but can also directly affect host cell signaling to aid bacterial spread and survival. In this review we will discuss the recent advances in the field of bacterial adhesion, how we are beginning to unravel the effects adhesins have on host cell signaling, and how these changes aid the bacteria in terms of their survival and evasion of immune responses. Finally, we will highlight how the exploitation of bacterial adhesins may provide new therapeutic avenues for the treatment of a wide range of bacterial infections.

KW - adhesion

KW - adhesin

KW - cell-signaling

KW - host–pathogen interaction

KW - bacterial attachment

KW - anti-adhesion therapy

U2 - 10.3390/ijms16022626

DO - 10.3390/ijms16022626

M3 - Article

C2 - 25625516

VL - 16

SP - 2626

EP - 2640

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 2

ER -