Projects per year
Abstract
The ability of bacterial species to colonize and infect host organisms is critically dependent upon their capacity to adhere to cellular surfaces of the host. Adherence to cell surfaces is known to be essential for the activation and delivery of certain virulence factors, but can also directly affect host cell signaling to aid bacterial spread and survival. In this review we will discuss the recent advances in the field of bacterial adhesion, how we are beginning to unravel the effects adhesins have on host cell signaling, and how these changes aid the bacteria in terms of their survival and evasion of immune responses. Finally, we will highlight how the exploitation of bacterial adhesins may provide new therapeutic avenues for the treatment of a wide range of bacterial infections.
Original language | English |
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Pages (from-to) | 2626-2640 |
Number of pages | 15 |
Journal | International Journal of Molecular Sciences |
Volume | 16 |
Issue number | 2 |
DOIs | |
Publication status | Published - 23 Jan 2015 |
Keywords
- adhesion
- adhesin
- cell-signaling
- host–pathogen interaction
- bacterial attachment
- anti-adhesion therapy
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Dive into the research topics of 'Fatal attraction : how bacterial adhesins affect host signaling and what we can learn from them'. Together they form a unique fingerprint.Projects
- 2 Finished
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Molecular mechanisms modulating host epithelial integrity in response to bacterial adhesion
Biotechnology & Biological Sciences Research Council
1/08/15 → 31/07/18
Project: Research Councils
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Molecular and functional characterization of protein-lipid interactions at the bacterial host interface
Krachler, A.
Biotechnology & Biological Sciences Research Council
1/04/14 → 31/03/17
Project: Research Councils