Fatal attraction : how bacterial adhesins affect host signaling and what we can learn from them

Research output: Contribution to journalArticlepeer-review

Colleges, School and Institutes

Abstract

The ability of bacterial species to colonize and infect host organisms is critically dependent upon their capacity to adhere to cellular surfaces of the host. Adherence to cell surfaces is known to be essential for the activation and delivery of certain virulence factors, but can also directly affect host cell signaling to aid bacterial spread and survival. In this review we will discuss the recent advances in the field of bacterial adhesion, how we are beginning to unravel the effects adhesins have on host cell signaling, and how these changes aid the bacteria in terms of their survival and evasion of immune responses. Finally, we will highlight how the exploitation of bacterial adhesins may provide new therapeutic avenues for the treatment of a wide range of bacterial infections.

Details

Original languageEnglish
Pages (from-to)2626-2640
Number of pages15
JournalInternational Journal of Molecular Sciences
Volume16
Issue number2
Publication statusPublished - 23 Jan 2015

Keywords

  • adhesion, adhesin, cell-signaling, host–pathogen interaction, bacterial attachment, anti-adhesion therapy