Face/Off: the interchangeable side of Candida albicans

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Face/Off : the interchangeable side of Candida albicans. / Cottier, Fabien; Hall, Rebecca.

In: Frontiers in cellular and infection microbiology, Vol. 9, 471, 28.01.2020, p. 1-10.

Research output: Contribution to journalReview articlepeer-review

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@article{277f6c9ecd28406596e5af546627443d,
title = "Face/Off: the interchangeable side of Candida albicans",
abstract = "Due to limited mobility, fungi, like most unicellular organisms, have evolved mechanisms to adapt to sudden chemical and/or physical variation in their environment. Candida albicans is recognised as a model organism to study eukaryotic responses to environmental changes, as this human commensal yeast but also opportunistic pathogen responds to numerous environmental cues through switching morphologies from yeast to hyphae growth. This mechanism is largely controlled by two major pathways: cAMP-PKA and MAPK, but each environmental signal is sensed by specific sensors. However, morphological switching is not the only response C. albicans exerts in response to environmental cues. Recently, fungal cell wall remodelling in response to host derived environmental cues has been identified as a way for C. albicans to manipulate the innate immune system. The fungal cell wall is composed of a chitin skeleton linked to a network of β-glucan, which anchors proteins and mannans to the fungal cell surface. As localised on the cell surface, these molecules drive interactions with the environment and other cells, particularly with host immune cells. C. albicans is recognised by immune cells such as neutrophils and macrophages via Pathogen Recognition Receptors (PRRs) which bind different components of the cell wall. While β-glucan and mannan are pro-inflammatory molecules, chitin can induce anti-inflammatory responses. Interestingly, C. albicans is able to regulate the exposure of these Pathogen Associated Molecular Patterns (PAMPs) according to environmental cues resulting in a modulation of the host immune response. This review describes the mechanisms involved in C. albicans response to environmental changes and their effect on immune recognition.",
keywords = "Candida, cell wall, innate immnuity, morphogeneis, cell wall remodelling",
author = "Fabien Cottier and Rebecca Hall",
year = "2020",
month = jan,
day = "28",
doi = "10.3389/fcimb.2019.00471",
language = "English",
volume = "9",
pages = "1--10",
journal = "Frontiers in cellular and infection microbiology",
issn = "2235-2988",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Face/Off

T2 - the interchangeable side of Candida albicans

AU - Cottier, Fabien

AU - Hall, Rebecca

PY - 2020/1/28

Y1 - 2020/1/28

N2 - Due to limited mobility, fungi, like most unicellular organisms, have evolved mechanisms to adapt to sudden chemical and/or physical variation in their environment. Candida albicans is recognised as a model organism to study eukaryotic responses to environmental changes, as this human commensal yeast but also opportunistic pathogen responds to numerous environmental cues through switching morphologies from yeast to hyphae growth. This mechanism is largely controlled by two major pathways: cAMP-PKA and MAPK, but each environmental signal is sensed by specific sensors. However, morphological switching is not the only response C. albicans exerts in response to environmental cues. Recently, fungal cell wall remodelling in response to host derived environmental cues has been identified as a way for C. albicans to manipulate the innate immune system. The fungal cell wall is composed of a chitin skeleton linked to a network of β-glucan, which anchors proteins and mannans to the fungal cell surface. As localised on the cell surface, these molecules drive interactions with the environment and other cells, particularly with host immune cells. C. albicans is recognised by immune cells such as neutrophils and macrophages via Pathogen Recognition Receptors (PRRs) which bind different components of the cell wall. While β-glucan and mannan are pro-inflammatory molecules, chitin can induce anti-inflammatory responses. Interestingly, C. albicans is able to regulate the exposure of these Pathogen Associated Molecular Patterns (PAMPs) according to environmental cues resulting in a modulation of the host immune response. This review describes the mechanisms involved in C. albicans response to environmental changes and their effect on immune recognition.

AB - Due to limited mobility, fungi, like most unicellular organisms, have evolved mechanisms to adapt to sudden chemical and/or physical variation in their environment. Candida albicans is recognised as a model organism to study eukaryotic responses to environmental changes, as this human commensal yeast but also opportunistic pathogen responds to numerous environmental cues through switching morphologies from yeast to hyphae growth. This mechanism is largely controlled by two major pathways: cAMP-PKA and MAPK, but each environmental signal is sensed by specific sensors. However, morphological switching is not the only response C. albicans exerts in response to environmental cues. Recently, fungal cell wall remodelling in response to host derived environmental cues has been identified as a way for C. albicans to manipulate the innate immune system. The fungal cell wall is composed of a chitin skeleton linked to a network of β-glucan, which anchors proteins and mannans to the fungal cell surface. As localised on the cell surface, these molecules drive interactions with the environment and other cells, particularly with host immune cells. C. albicans is recognised by immune cells such as neutrophils and macrophages via Pathogen Recognition Receptors (PRRs) which bind different components of the cell wall. While β-glucan and mannan are pro-inflammatory molecules, chitin can induce anti-inflammatory responses. Interestingly, C. albicans is able to regulate the exposure of these Pathogen Associated Molecular Patterns (PAMPs) according to environmental cues resulting in a modulation of the host immune response. This review describes the mechanisms involved in C. albicans response to environmental changes and their effect on immune recognition.

KW - Candida

KW - cell wall

KW - innate immnuity

KW - morphogeneis

KW - cell wall remodelling

U2 - 10.3389/fcimb.2019.00471

DO - 10.3389/fcimb.2019.00471

M3 - Review article

C2 - 32047726

VL - 9

SP - 1

EP - 10

JO - Frontiers in cellular and infection microbiology

JF - Frontiers in cellular and infection microbiology

SN - 2235-2988

M1 - 471

ER -