Extracorporeal photopheresis for the treatment of Crohn's disease

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Extracorporeal photopheresis for the treatment of Crohn's disease. / Fowler, Sharyle; Jones, Jennifer; Hull, Peter R; Ghosh, Subrata.

In: Transfusion and Apheresis Science, Vol. 52, No. 2, 04.2015, p. 183-186.

Research output: Contribution to journalReview articlepeer-review

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Fowler, Sharyle ; Jones, Jennifer ; Hull, Peter R ; Ghosh, Subrata. / Extracorporeal photopheresis for the treatment of Crohn's disease. In: Transfusion and Apheresis Science. 2015 ; Vol. 52, No. 2. pp. 183-186.

Bibtex

@article{39156c3d81d942c4b743dde96f24db0e,
title = "Extracorporeal photopheresis for the treatment of Crohn's disease",
abstract = "Small, open-label studies show promising results for ECP in the treatment of steroid-dependent and medically-refractory Crohn's disease. However, proper randomized, sham-controlled trials have not yet been performed. Based on the proposed mechanism of action of ECP, induction of a tolerogenic T cell response, ECP should be assessed in patients with early inflammatory disease rather than those who have progressed to fibrotic or stricturing disease. Randomized, sham-controlled trials need to be performed before ECP can be incorporated into standard clinical practice for the treatment of Crohn's disease.",
keywords = "Blood Component Removal, Clinical Trials as Topic, Crohn Disease, Humans, Immunosuppressive Agents, Inflammation, Photopheresis, Research Design, Steroids, T-Lymphocytes, Treatment Outcome, Journal Article, Review",
author = "Sharyle Fowler and Jennifer Jones and Hull, {Peter R} and Subrata Ghosh",
note = "Copyright {\textcopyright} 2015 Elsevier Ltd. All rights reserved.",
year = "2015",
month = apr,
doi = "10.1016/j.transci.2015.02.006",
language = "English",
volume = "52",
pages = "183--186",
journal = "Transfusion and Apheresis Science",
issn = "1473-0502",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Extracorporeal photopheresis for the treatment of Crohn's disease

AU - Fowler, Sharyle

AU - Jones, Jennifer

AU - Hull, Peter R

AU - Ghosh, Subrata

N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.

PY - 2015/4

Y1 - 2015/4

N2 - Small, open-label studies show promising results for ECP in the treatment of steroid-dependent and medically-refractory Crohn's disease. However, proper randomized, sham-controlled trials have not yet been performed. Based on the proposed mechanism of action of ECP, induction of a tolerogenic T cell response, ECP should be assessed in patients with early inflammatory disease rather than those who have progressed to fibrotic or stricturing disease. Randomized, sham-controlled trials need to be performed before ECP can be incorporated into standard clinical practice for the treatment of Crohn's disease.

AB - Small, open-label studies show promising results for ECP in the treatment of steroid-dependent and medically-refractory Crohn's disease. However, proper randomized, sham-controlled trials have not yet been performed. Based on the proposed mechanism of action of ECP, induction of a tolerogenic T cell response, ECP should be assessed in patients with early inflammatory disease rather than those who have progressed to fibrotic or stricturing disease. Randomized, sham-controlled trials need to be performed before ECP can be incorporated into standard clinical practice for the treatment of Crohn's disease.

KW - Blood Component Removal

KW - Clinical Trials as Topic

KW - Crohn Disease

KW - Humans

KW - Immunosuppressive Agents

KW - Inflammation

KW - Photopheresis

KW - Research Design

KW - Steroids

KW - T-Lymphocytes

KW - Treatment Outcome

KW - Journal Article

KW - Review

U2 - 10.1016/j.transci.2015.02.006

DO - 10.1016/j.transci.2015.02.006

M3 - Review article

C2 - 25747960

VL - 52

SP - 183

EP - 186

JO - Transfusion and Apheresis Science

JF - Transfusion and Apheresis Science

SN - 1473-0502

IS - 2

ER -