TY - JOUR
T1 - Extracellular matrix biology: a new frontier in linking the pathology and therapy of hypertension
AU - Tayebjee, Muzahir
AU - Macfadyen, Robert
AU - Lip, Gregory
PY - 2003/12/1
Y1 - 2003/12/1
N2 - The extracellular matrix (ECM) is a vital component of connective tissue, and collagen is a major constituent. There is growing evidence that changes in the composition of the cardiac and vascular matrix occurs during hypertension. Clinically, these effects are manifested as left ventricular hypertrophy and a reduction in arterial compliance and luminal diameter, which results in end organ ischaemia. The matrix metalloproteinases and their inhibitors have a central role in the regulation of the composition of the ECM. In this review, we discuss the mediators that affect the structure of the ECM in hypertension using results from animal and human studies.
AB - The extracellular matrix (ECM) is a vital component of connective tissue, and collagen is a major constituent. There is growing evidence that changes in the composition of the cardiac and vascular matrix occurs during hypertension. Clinically, these effects are manifested as left ventricular hypertrophy and a reduction in arterial compliance and luminal diameter, which results in end organ ischaemia. The matrix metalloproteinases and their inhibitors have a central role in the regulation of the composition of the ECM. In this review, we discuss the mediators that affect the structure of the ECM in hypertension using results from animal and human studies.
UR - http://www.scopus.com/inward/record.url?scp=1442299090&partnerID=8YFLogxK
U2 - 10.1097/00004872-200312000-00002
DO - 10.1097/00004872-200312000-00002
M3 - Review article
C2 - 14654734
SN - 1473-5598
VL - 21
SP - 2211
EP - 2218
JO - Journal of Hypertension
JF - Journal of Hypertension
IS - 12
ER -