Extended-Spectrum beta-Lactamase Genes of Escherichia coli in Chicken Meat and Humans, the Netherlands

I Overdevest; I Willemsen; M Rijnsburger; A Eustace; Li McCrae; Peter Hawkey; M Heck; P Savelkoul; C Vandenbroucke-Grauls; K van der Zwaluw; X Huijsdens; J Kluytmans

doi:10.3201/eid1707.110209

Extended-Spectrum beta-Lactamase Genes of Escherichia coli in Chicken Meat and Humans, the Netherlands

I Overdevest, I Willemsen, M Rijnsburger, A Eustace, Li McCrae, Peter Hawkey, M Heck, P Savelkoul, C Vandenbroucke-Grauls, K van der Zwaluw, X Huijsdens, J Kluytmans

Immunology and Immunotherapy

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381 Citations (Scopus)

Abstract

We determined the prevalence and characteristics of extended-spectrum beta-lactamase (ESBL) genes of Enterobacteriaceae in retail chicken meat and humans in the Netherlands. Raw meat samples were obtained, and simultaneous cross-sectional surveys of fecal carriage were performed in 4 hospitals in the same area. Human blood cultures from these hospitals that contained ESBL genes were included. A high prevalence of ESBL genes was found in chicken meat (79.8%). Genetic analysis showed that the predominant ESBL genes in chicken meat and human rectal swab specimens were identical. These genes were also frequently found in human blood culture isolates. Typing results of Escherichia coli strains showed a high degree of similarity with strains from meat and humans. These findings suggest that the abundant presence of ESBL genes in the food chain may have a profound effect on future treatment options for a wide range of infections caused by gram-negative bacteria.

Original language	English
Pages (from-to)	1216-1222
Number of pages	7
Journal	Emerging infectious diseases
Volume	17
Issue number	7
DOIs	https://doi.org/10.3201/eid1707.110209
Publication status	Published - 1 Jul 2011

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Overdevest, I., Willemsen, I., Rijnsburger, M., Eustace, A., McCrae, L., Hawkey, P., Heck, M., Savelkoul, P., Vandenbroucke-Grauls, C., van der Zwaluw, K., Huijsdens, X., & Kluytmans, J. (2011). Extended-Spectrum beta-Lactamase Genes of Escherichia coli in Chicken Meat and Humans, the Netherlands. Emerging infectious diseases, 17(7), 1216-1222. https://doi.org/10.3201/eid1707.110209

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title = "Extended-Spectrum beta-Lactamase Genes of Escherichia coli in Chicken Meat and Humans, the Netherlands",

abstract = "We determined the prevalence and characteristics of extended-spectrum beta-lactamase (ESBL) genes of Enterobacteriaceae in retail chicken meat and humans in the Netherlands. Raw meat samples were obtained, and simultaneous cross-sectional surveys of fecal carriage were performed in 4 hospitals in the same area. Human blood cultures from these hospitals that contained ESBL genes were included. A high prevalence of ESBL genes was found in chicken meat (79.8%). Genetic analysis showed that the predominant ESBL genes in chicken meat and human rectal swab specimens were identical. These genes were also frequently found in human blood culture isolates. Typing results of Escherichia coli strains showed a high degree of similarity with strains from meat and humans. These findings suggest that the abundant presence of ESBL genes in the food chain may have a profound effect on future treatment options for a wide range of infections caused by gram-negative bacteria.",

author = "I Overdevest and I Willemsen and M Rijnsburger and A Eustace and Li McCrae and Peter Hawkey and M Heck and P Savelkoul and C Vandenbroucke-Grauls and {van der Zwaluw}, K and X Huijsdens and J Kluytmans",

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doi = "10.3201/eid1707.110209",

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Overdevest, I, Willemsen, I, Rijnsburger, M, Eustace, A, McCrae, L, Hawkey, P, Heck, M, Savelkoul, P, Vandenbroucke-Grauls, C, van der Zwaluw, K, Huijsdens, X & Kluytmans, J 2011, 'Extended-Spectrum beta-Lactamase Genes of Escherichia coli in Chicken Meat and Humans, the Netherlands', Emerging infectious diseases, vol. 17, no. 7, pp. 1216-1222. https://doi.org/10.3201/eid1707.110209

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T1 - Extended-Spectrum beta-Lactamase Genes of Escherichia coli in Chicken Meat and Humans, the Netherlands

AU - Overdevest, I

AU - Willemsen, I

AU - Rijnsburger, M

AU - Eustace, A

AU - McCrae, Li

AU - Hawkey, Peter

AU - Heck, M

AU - Savelkoul, P

AU - Vandenbroucke-Grauls, C

AU - van der Zwaluw, K

AU - Huijsdens, X

AU - Kluytmans, J

PY - 2011/7/1

Y1 - 2011/7/1

N2 - We determined the prevalence and characteristics of extended-spectrum beta-lactamase (ESBL) genes of Enterobacteriaceae in retail chicken meat and humans in the Netherlands. Raw meat samples were obtained, and simultaneous cross-sectional surveys of fecal carriage were performed in 4 hospitals in the same area. Human blood cultures from these hospitals that contained ESBL genes were included. A high prevalence of ESBL genes was found in chicken meat (79.8%). Genetic analysis showed that the predominant ESBL genes in chicken meat and human rectal swab specimens were identical. These genes were also frequently found in human blood culture isolates. Typing results of Escherichia coli strains showed a high degree of similarity with strains from meat and humans. These findings suggest that the abundant presence of ESBL genes in the food chain may have a profound effect on future treatment options for a wide range of infections caused by gram-negative bacteria.

AB - We determined the prevalence and characteristics of extended-spectrum beta-lactamase (ESBL) genes of Enterobacteriaceae in retail chicken meat and humans in the Netherlands. Raw meat samples were obtained, and simultaneous cross-sectional surveys of fecal carriage were performed in 4 hospitals in the same area. Human blood cultures from these hospitals that contained ESBL genes were included. A high prevalence of ESBL genes was found in chicken meat (79.8%). Genetic analysis showed that the predominant ESBL genes in chicken meat and human rectal swab specimens were identical. These genes were also frequently found in human blood culture isolates. Typing results of Escherichia coli strains showed a high degree of similarity with strains from meat and humans. These findings suggest that the abundant presence of ESBL genes in the food chain may have a profound effect on future treatment options for a wide range of infections caused by gram-negative bacteria.

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DO - 10.3201/eid1707.110209

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VL - 17

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EP - 1222

JO - Emerging infectious diseases

JF - Emerging infectious diseases

IS - 7

ER -

Extended-Spectrum beta-Lactamase Genes of Escherichia coli in Chicken Meat and Humans, the Netherlands

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