Expression patterns of fibroblast growth factors-18 and -20 in mouse embryos is suggestive of novel roles in calvarial and limb development.

Research output: Contribution to journalArticle

Colleges, School and Institutes

Abstract

The normal development of calvarial bones and sutures critically relies on proper signalling through Fgf receptors, but the source and identity of cognate ligands have remained unknown. Reverse transcriptase polymerase chain reaction analysis in this study shows that a broad range of Fgf ligands are expressed in the coronal sutures separating the parietal and frontal bones. Analysis by whole mount in situ hybridization further reveals distinct expression patterns for Fgf-18, Fgf-20, and by comparison, Fgf-9, in the calvaria, and Fgfs-20 and -9 in the developing limbs, suggestive of their role in proliferation, differentiation and apoptosis.

Details

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalMechanisms of Development
Volume113
Issue number1
Publication statusPublished - 1 Apr 2002

Keywords

  • limb development, craniosynostosis, sutures, Fgf-20, mesenchymal cells, bone, in situ hybridization, calvaria, Fgf-18, Fgf-9, reverse transcriptase polymerase chain reaction, cranial cartilage