Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11)

Riana Cockeran; Jenny A Herbert; Timothy J Mitchell; Thérèse Dix-Peek; Caroline Dickens; Ronald Anderson; Charles Feldman

doi:10.1155/2014/976347

Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11)

Riana Cockeran, Jenny A Herbert, Timothy J Mitchell, Thérèse Dix-Peek, Caroline Dickens, Ronald Anderson, Charles Feldman

Microbiology and Infection

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Alterations in whole genome expression profiles following exposure of the pneumococcus (strain 172, serotype 23F) to cigarette smoke condensate (160 μg/mL) for 15 and 60 min have been determined using the TIGR4 DNA microarray chip. Exposure to CSC resulted in the significant (P<0.014-0.0006) upregulation of the genes encoding the two-component regulatory system 11 (TCS11), consisting of the sensor kinase, hk11, and its cognate response regulator, rr11, in the setting of increased biofilm formation. These effects of cigarette smoke on the pneumococcus may contribute to colonization of the airways by this microbial pathogen.

Original language	English
Article number	976347
Journal	BioMed Central
Volume	2014
DOIs	https://doi.org/10.1155/2014/976347
Publication status	Published - 11 Jun 2014

Keywords

Bacterial Proteins
DNA-Binding Proteins
Gene Expression Regulation, Bacterial
Membrane Proteins
Oligonucleotide Array Sequence Analysis
Protein Kinases
Serogroup
Smoking
Streptococcus pneumoniae

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Cockeran, R., Herbert, J. A., Mitchell, T. J., Dix-Peek, T., Dickens, C., Anderson, R., & Feldman, C. (2014). Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11). BioMed Central, 2014, Article 976347. https://doi.org/10.1155/2014/976347

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abstract = "Alterations in whole genome expression profiles following exposure of the pneumococcus (strain 172, serotype 23F) to cigarette smoke condensate (160 μg/mL) for 15 and 60 min have been determined using the TIGR4 DNA microarray chip. Exposure to CSC resulted in the significant (P<0.014-0.0006) upregulation of the genes encoding the two-component regulatory system 11 (TCS11), consisting of the sensor kinase, hk11, and its cognate response regulator, rr11, in the setting of increased biofilm formation. These effects of cigarette smoke on the pneumococcus may contribute to colonization of the airways by this microbial pathogen.",

keywords = "Bacterial Proteins, DNA-Binding Proteins, Gene Expression Regulation, Bacterial, Membrane Proteins, Oligonucleotide Array Sequence Analysis, Protein Kinases, Serogroup, Smoking, Streptococcus pneumoniae",

author = "Riana Cockeran and Herbert, {Jenny A} and Mitchell, {Timothy J} and Th{\'e}r{\`e}se Dix-Peek and Caroline Dickens and Ronald Anderson and Charles Feldman",

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language = "English",

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Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11). / Cockeran, Riana; Herbert, Jenny A; Mitchell, Timothy J et al.
In: BioMed Central, Vol. 2014, 976347, 11.06.2014.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11)

AU - Cockeran, Riana

AU - Herbert, Jenny A

AU - Mitchell, Timothy J

AU - Dix-Peek, Thérèse

AU - Dickens, Caroline

AU - Anderson, Ronald

AU - Feldman, Charles

PY - 2014/6/11

Y1 - 2014/6/11

N2 - Alterations in whole genome expression profiles following exposure of the pneumococcus (strain 172, serotype 23F) to cigarette smoke condensate (160 μg/mL) for 15 and 60 min have been determined using the TIGR4 DNA microarray chip. Exposure to CSC resulted in the significant (P<0.014-0.0006) upregulation of the genes encoding the two-component regulatory system 11 (TCS11), consisting of the sensor kinase, hk11, and its cognate response regulator, rr11, in the setting of increased biofilm formation. These effects of cigarette smoke on the pneumococcus may contribute to colonization of the airways by this microbial pathogen.

AB - Alterations in whole genome expression profiles following exposure of the pneumococcus (strain 172, serotype 23F) to cigarette smoke condensate (160 μg/mL) for 15 and 60 min have been determined using the TIGR4 DNA microarray chip. Exposure to CSC resulted in the significant (P<0.014-0.0006) upregulation of the genes encoding the two-component regulatory system 11 (TCS11), consisting of the sensor kinase, hk11, and its cognate response regulator, rr11, in the setting of increased biofilm formation. These effects of cigarette smoke on the pneumococcus may contribute to colonization of the airways by this microbial pathogen.

KW - Bacterial Proteins

KW - DNA-Binding Proteins

KW - Gene Expression Regulation, Bacterial

KW - Membrane Proteins

KW - Oligonucleotide Array Sequence Analysis

KW - Protein Kinases

KW - Serogroup

KW - Smoking

KW - Streptococcus pneumoniae

U2 - 10.1155/2014/976347

DO - 10.1155/2014/976347

M3 - Article

C2 - 25013815

VL - 2014

JO - BioMed Central

JF - BioMed Central

M1 - 976347

ER -

Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11)

Abstract

Keywords

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