TY - JOUR
T1 - Exploring the pathogenesis of idiopathic intracranial hypertension:: An inflammatory perspective
AU - Sinclair, Alexandra
AU - Ball, Alexandra
AU - Burdon, Michael
AU - Clarke, Carl
AU - Stewart, Paul
AU - Curnow, Stephen
AU - Rauz, Saaeha
PY - 2008/9/15
Y1 - 2008/9/15
N2 - Idiopathic intracranial hypertension (IIH) is a common blinding condition amongst the young obese female population (20 per 100,000) characterised by elevated intracranial pressure (ICP). The aetiology of IIH is not known. In this review we explore the literature investigating the pathogenesis of IIH and suggest additional hypotheses. Chronic inflammation is emerging as an aetiological factor in the pathogenesis of obesity and we propose that this may be a feature of IIH. Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.
AB - Idiopathic intracranial hypertension (IIH) is a common blinding condition amongst the young obese female population (20 per 100,000) characterised by elevated intracranial pressure (ICP). The aetiology of IIH is not known. In this review we explore the literature investigating the pathogenesis of IIH and suggest additional hypotheses. Chronic inflammation is emerging as an aetiological factor in the pathogenesis of obesity and we propose that this may be a feature of IIH. Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.
KW - Obesity
KW - 11 beta-hydroxysteroid dehydrogenase
KW - Idiopathic intracranial hypertension
KW - Chronic inflammation
U2 - 10.1016/j.jneuroim.2008.06.029
DO - 10.1016/j.jneuroim.2008.06.029
M3 - Article
C2 - 18676028
SN - 1872-8421
VL - 201-202
SP - 212
EP - 220
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
ER -
