Exploring the pathogenesis of idiopathic intracranial hypertension:: An inflammatory perspective

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@article{322e6d7b7cb541e581d8b31d50334c5f,
title = "Exploring the pathogenesis of idiopathic intracranial hypertension:: An inflammatory perspective",
abstract = "Idiopathic intracranial hypertension (IIH) is a common blinding condition amongst the young obese female population (20 per 100,000) characterised by elevated intracranial pressure (ICP). The aetiology of IIH is not known. In this review we explore the literature investigating the pathogenesis of IIH and suggest additional hypotheses. Chronic inflammation is emerging as an aetiological factor in the pathogenesis of obesity and we propose that this may be a feature of IIH. Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.",
keywords = "Obesity, 11 beta-hydroxysteroid dehydrogenase, Idiopathic intracranial hypertension, Chronic inflammation",
author = "Alexandra Sinclair and Alexandra Ball and Michael Burdon and Carl Clarke and Paul Stewart and Stephen Curnow and Saaeha Rauz",
year = "2008",
month = sep,
day = "15",
doi = "10.1016/j.jneuroim.2008.06.029",
language = "English",
volume = "201-202",
pages = "212--220",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Exploring the pathogenesis of idiopathic intracranial hypertension:: An inflammatory perspective

AU - Sinclair, Alexandra

AU - Ball, Alexandra

AU - Burdon, Michael

AU - Clarke, Carl

AU - Stewart, Paul

AU - Curnow, Stephen

AU - Rauz, Saaeha

PY - 2008/9/15

Y1 - 2008/9/15

N2 - Idiopathic intracranial hypertension (IIH) is a common blinding condition amongst the young obese female population (20 per 100,000) characterised by elevated intracranial pressure (ICP). The aetiology of IIH is not known. In this review we explore the literature investigating the pathogenesis of IIH and suggest additional hypotheses. Chronic inflammation is emerging as an aetiological factor in the pathogenesis of obesity and we propose that this may be a feature of IIH. Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.

AB - Idiopathic intracranial hypertension (IIH) is a common blinding condition amongst the young obese female population (20 per 100,000) characterised by elevated intracranial pressure (ICP). The aetiology of IIH is not known. In this review we explore the literature investigating the pathogenesis of IIH and suggest additional hypotheses. Chronic inflammation is emerging as an aetiological factor in the pathogenesis of obesity and we propose that this may be a feature of IIH. Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.

KW - Obesity

KW - 11 beta-hydroxysteroid dehydrogenase

KW - Idiopathic intracranial hypertension

KW - Chronic inflammation

U2 - 10.1016/j.jneuroim.2008.06.029

DO - 10.1016/j.jneuroim.2008.06.029

M3 - Article

C2 - 18676028

VL - 201-202

SP - 212

EP - 220

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

ER -