Exploring the enzymatic degradation of poly(glycerol adipate)

Research output: Contribution to journalArticle

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Exploring the enzymatic degradation of poly(glycerol adipate). / Swainson, Sadie M.E.; Taresco, Vincenzo; Pearce, Amanda K.; Clapp, Lucie H.; Ager, B.; McAllister, Mark; Bosquillon, Cynthia; Garnett, Martin C.

In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 142, 01.09.2019, p. 377-386.

Research output: Contribution to journalArticle

Harvard

Swainson, SME, Taresco, V, Pearce, AK, Clapp, LH, Ager, B, McAllister, M, Bosquillon, C & Garnett, MC 2019, 'Exploring the enzymatic degradation of poly(glycerol adipate)', European Journal of Pharmaceutics and Biopharmaceutics, vol. 142, pp. 377-386. https://doi.org/10.1016/j.ejpb.2019.07.015

APA

Swainson, S. M. E., Taresco, V., Pearce, A. K., Clapp, L. H., Ager, B., McAllister, M., Bosquillon, C., & Garnett, M. C. (2019). Exploring the enzymatic degradation of poly(glycerol adipate). European Journal of Pharmaceutics and Biopharmaceutics, 142, 377-386. https://doi.org/10.1016/j.ejpb.2019.07.015

Vancouver

Author

Swainson, Sadie M.E. ; Taresco, Vincenzo ; Pearce, Amanda K. ; Clapp, Lucie H. ; Ager, B. ; McAllister, Mark ; Bosquillon, Cynthia ; Garnett, Martin C. / Exploring the enzymatic degradation of poly(glycerol adipate). In: European Journal of Pharmaceutics and Biopharmaceutics. 2019 ; Vol. 142. pp. 377-386.

Bibtex

@article{7c40f716c4b34507b08e8cdd597d2344,
title = "Exploring the enzymatic degradation of poly(glycerol adipate)",
abstract = "Poly(glycerol adipate) (PGA) is a biodegradable, biocompatible, polymer with a great deal of potential in the field of drug delivery. Active drug molecules can be conjugated to the polymer backbone or encapsulated in self-assembled nanoparticles for targeted and systemic delivery. Here, a range of techniques have been used to characterise the enzymatic degradation of PGA extensively for the first time and to provide an indication of the way the polymer will behave and release drug payloads in vivo. Dynamic Light Scattering was used to monitor change in nanoparticle size, indicative of degradation. The release of a fluorescent dye, coupled to PGA, upon incubation with enzymes was measured over a 96 h period as a model of drug release from polymer drug conjugates. The changes to the chemical structure and molecular weight of PGA following enzyme exposure were characterised using FTIR, NMR and GPC. These techniques provided evidence of the biodegradability of PGA, its susceptibility to degradation by a range of enzymes commonly found in the human body and the polymer's potential as a drug delivery platform.",
keywords = "Biodegradable, Breakdown, Enzymatic degradation, Poly(glycerol adipate), Polyester, Polymer modification",
author = "Swainson, {Sadie M.E.} and Vincenzo Taresco and Pearce, {Amanda K.} and Clapp, {Lucie H.} and B. Ager and Mark McAllister and Cynthia Bosquillon and Garnett, {Martin C.}",
year = "2019",
month = sep,
day = "1",
doi = "10.1016/j.ejpb.2019.07.015",
language = "English",
volume = "142",
pages = "377--386",
journal = "European Journal of Pharmaceutics and Biopharmaceutics",
issn = "0939-6411",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Exploring the enzymatic degradation of poly(glycerol adipate)

AU - Swainson, Sadie M.E.

AU - Taresco, Vincenzo

AU - Pearce, Amanda K.

AU - Clapp, Lucie H.

AU - Ager, B.

AU - McAllister, Mark

AU - Bosquillon, Cynthia

AU - Garnett, Martin C.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Poly(glycerol adipate) (PGA) is a biodegradable, biocompatible, polymer with a great deal of potential in the field of drug delivery. Active drug molecules can be conjugated to the polymer backbone or encapsulated in self-assembled nanoparticles for targeted and systemic delivery. Here, a range of techniques have been used to characterise the enzymatic degradation of PGA extensively for the first time and to provide an indication of the way the polymer will behave and release drug payloads in vivo. Dynamic Light Scattering was used to monitor change in nanoparticle size, indicative of degradation. The release of a fluorescent dye, coupled to PGA, upon incubation with enzymes was measured over a 96 h period as a model of drug release from polymer drug conjugates. The changes to the chemical structure and molecular weight of PGA following enzyme exposure were characterised using FTIR, NMR and GPC. These techniques provided evidence of the biodegradability of PGA, its susceptibility to degradation by a range of enzymes commonly found in the human body and the polymer's potential as a drug delivery platform.

AB - Poly(glycerol adipate) (PGA) is a biodegradable, biocompatible, polymer with a great deal of potential in the field of drug delivery. Active drug molecules can be conjugated to the polymer backbone or encapsulated in self-assembled nanoparticles for targeted and systemic delivery. Here, a range of techniques have been used to characterise the enzymatic degradation of PGA extensively for the first time and to provide an indication of the way the polymer will behave and release drug payloads in vivo. Dynamic Light Scattering was used to monitor change in nanoparticle size, indicative of degradation. The release of a fluorescent dye, coupled to PGA, upon incubation with enzymes was measured over a 96 h period as a model of drug release from polymer drug conjugates. The changes to the chemical structure and molecular weight of PGA following enzyme exposure were characterised using FTIR, NMR and GPC. These techniques provided evidence of the biodegradability of PGA, its susceptibility to degradation by a range of enzymes commonly found in the human body and the polymer's potential as a drug delivery platform.

KW - Biodegradable

KW - Breakdown

KW - Enzymatic degradation

KW - Poly(glycerol adipate)

KW - Polyester

KW - Polymer modification

UR - http://www.scopus.com/inward/record.url?scp=85069595050&partnerID=8YFLogxK

U2 - 10.1016/j.ejpb.2019.07.015

DO - 10.1016/j.ejpb.2019.07.015

M3 - Article

C2 - 31319123

AN - SCOPUS:85069595050

VL - 142

SP - 377

EP - 386

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

SN - 0939-6411

ER -