Existence of long-lasting experience-dependent plasticity in endocrine cell networks

Research output: Contribution to journalArticlepeer-review

Standard

Existence of long-lasting experience-dependent plasticity in endocrine cell networks. / Hodson, David J; Schaeffer, Marie; Romanò, Nicola; Fontanaud, Pierre; Lafont, Chrystel; Birkenstock, Jerome; Molino, François; Christian, Helen; Lockey, Joe; Carmignac, Danielle; Fernandez-Fuente, Marta; Le Tissier, Paul; Mollard, Patrice.

In: Nature Communications, Vol. 3, 2012, p. 605.

Research output: Contribution to journalArticlepeer-review

Harvard

Hodson, DJ, Schaeffer, M, Romanò, N, Fontanaud, P, Lafont, C, Birkenstock, J, Molino, F, Christian, H, Lockey, J, Carmignac, D, Fernandez-Fuente, M, Le Tissier, P & Mollard, P 2012, 'Existence of long-lasting experience-dependent plasticity in endocrine cell networks', Nature Communications, vol. 3, pp. 605. https://doi.org/10.1038/ncomms1612

APA

Hodson, D. J., Schaeffer, M., Romanò, N., Fontanaud, P., Lafont, C., Birkenstock, J., Molino, F., Christian, H., Lockey, J., Carmignac, D., Fernandez-Fuente, M., Le Tissier, P., & Mollard, P. (2012). Existence of long-lasting experience-dependent plasticity in endocrine cell networks. Nature Communications, 3, 605. https://doi.org/10.1038/ncomms1612

Vancouver

Author

Hodson, David J ; Schaeffer, Marie ; Romanò, Nicola ; Fontanaud, Pierre ; Lafont, Chrystel ; Birkenstock, Jerome ; Molino, François ; Christian, Helen ; Lockey, Joe ; Carmignac, Danielle ; Fernandez-Fuente, Marta ; Le Tissier, Paul ; Mollard, Patrice. / Existence of long-lasting experience-dependent plasticity in endocrine cell networks. In: Nature Communications. 2012 ; Vol. 3. pp. 605.

Bibtex

@article{2d84d06f9ca0400ab530ebf24ae55d3a,
title = "Existence of long-lasting experience-dependent plasticity in endocrine cell networks",
abstract = "Experience-dependent plasticity of cell and tissue function is critical for survival by allowing organisms to dynamically adjust physiological processes in response to changing or harsh environmental conditions. Despite the conferred evolutionary advantage, it remains unknown whether emergent experience-dependent properties are present in cell populations organized as networks within endocrine tissues involved in regulating body-wide homeostasis. Here we show, using lactation to repeatedly activate a specific endocrine cell network in situ in the mammalian pituitary, that templates of prior demand are permanently stored through stimulus-evoked alterations to the extent and strength of cell-cell connectivity. Strikingly, following repeat stimulation, evolved population behaviour leads to improved tissue output. As such, long-lasting experience-dependent plasticity is an important feature of endocrine cell networks and underlies functional adaptation of hormone release.",
keywords = "Adaptation, Physiological, Animals, Calcium, Cell Communication, Endocrine System, Female, Homeostasis, Lactation, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Models, Biological, Models, Theoretical, Photons, Pituitary Gland",
author = "Hodson, {David J} and Marie Schaeffer and Nicola Roman{\`o} and Pierre Fontanaud and Chrystel Lafont and Jerome Birkenstock and Fran{\c c}ois Molino and Helen Christian and Joe Lockey and Danielle Carmignac and Marta Fernandez-Fuente and {Le Tissier}, Paul and Patrice Mollard",
year = "2012",
doi = "10.1038/ncomms1612",
language = "English",
volume = "3",
pages = "605",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Existence of long-lasting experience-dependent plasticity in endocrine cell networks

AU - Hodson, David J

AU - Schaeffer, Marie

AU - Romanò, Nicola

AU - Fontanaud, Pierre

AU - Lafont, Chrystel

AU - Birkenstock, Jerome

AU - Molino, François

AU - Christian, Helen

AU - Lockey, Joe

AU - Carmignac, Danielle

AU - Fernandez-Fuente, Marta

AU - Le Tissier, Paul

AU - Mollard, Patrice

PY - 2012

Y1 - 2012

N2 - Experience-dependent plasticity of cell and tissue function is critical for survival by allowing organisms to dynamically adjust physiological processes in response to changing or harsh environmental conditions. Despite the conferred evolutionary advantage, it remains unknown whether emergent experience-dependent properties are present in cell populations organized as networks within endocrine tissues involved in regulating body-wide homeostasis. Here we show, using lactation to repeatedly activate a specific endocrine cell network in situ in the mammalian pituitary, that templates of prior demand are permanently stored through stimulus-evoked alterations to the extent and strength of cell-cell connectivity. Strikingly, following repeat stimulation, evolved population behaviour leads to improved tissue output. As such, long-lasting experience-dependent plasticity is an important feature of endocrine cell networks and underlies functional adaptation of hormone release.

AB - Experience-dependent plasticity of cell and tissue function is critical for survival by allowing organisms to dynamically adjust physiological processes in response to changing or harsh environmental conditions. Despite the conferred evolutionary advantage, it remains unknown whether emergent experience-dependent properties are present in cell populations organized as networks within endocrine tissues involved in regulating body-wide homeostasis. Here we show, using lactation to repeatedly activate a specific endocrine cell network in situ in the mammalian pituitary, that templates of prior demand are permanently stored through stimulus-evoked alterations to the extent and strength of cell-cell connectivity. Strikingly, following repeat stimulation, evolved population behaviour leads to improved tissue output. As such, long-lasting experience-dependent plasticity is an important feature of endocrine cell networks and underlies functional adaptation of hormone release.

KW - Adaptation, Physiological

KW - Animals

KW - Calcium

KW - Cell Communication

KW - Endocrine System

KW - Female

KW - Homeostasis

KW - Lactation

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Transgenic

KW - Models, Biological

KW - Models, Theoretical

KW - Photons

KW - Pituitary Gland

U2 - 10.1038/ncomms1612

DO - 10.1038/ncomms1612

M3 - Article

C2 - 22215080

VL - 3

SP - 605

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

ER -