Exhaled nitric oxide and pulmonary artery pressures during graded ascent to high altitude

Research output: Contribution to journalArticlepeer-review

Authors

  • J. Donnelly
  • K.N. Thomas
  • P.N. Ainslie
  • D.C. Cowan
  • G.P. Herbison
  • D.R. Taylor
  • D.J. Yeoman

Colleges, School and Institutes

External organisations

  • University of Otago
  • University of British Columbia

Abstract

Nitric oxide (NO) is a potent vasodilator that regulates pulmonary vascular tone. During ascent to high altitude, pulmonary vascular tone increases leading to pulmonary hypertension. To explore the mechanisms underpinning this effect, we investigated the relationship between exhaled NO (PENO; nmHg) and pulmonary artery systolic pressure (PASP; mmHg) in 11 healthy adults during hypoxic challenge at sea level [with oxygen saturations (SPO2) of 80% and 90%] and at intervals during graded ascent to 5050. m. During normobaric hypoxia, PASP progressively increased from 22.7. mmHg to 33.5. mmHg (p=0.006), whilst PENO remained unchanged. In contrast, during ascent to high altitude, PASP increased progressively from 22.7. mmHg to 39.1. mmHg (p

Details

Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalRespiratory physiology & neurobiology
Volume177
Issue number3
Publication statusPublished - 15 Aug 2011