TY - JOUR
T1 - Exhaled nitric oxide and pulmonary artery pressures during graded ascent to high altitude
AU - Donnelly, J.
AU - Lucas, S.J.E.
AU - Thomas, K.N.
AU - Ainslie, P.N.
AU - Cowan, D.C.
AU - Herbison, G.P.
AU - Taylor, D.R.
AU - Yeoman, D.J.
PY - 2011/8/15
Y1 - 2011/8/15
N2 - Nitric oxide (NO) is a potent vasodilator that regulates pulmonary vascular tone. During ascent to high altitude, pulmonary vascular tone increases leading to pulmonary hypertension. To explore the mechanisms underpinning this effect, we investigated the relationship between exhaled NO (PENO; nmHg) and pulmonary artery systolic pressure (PASP; mmHg) in 11 healthy adults during hypoxic challenge at sea level [with oxygen saturations (SPO2) of 80% and 90%] and at intervals during graded ascent to 5050. m. During normobaric hypoxia, PASP progressively increased from 22.7. mmHg to 33.5. mmHg (p=0.006), whilst PENO remained unchanged. In contrast, during ascent to high altitude, PASP increased progressively from 22.7. mmHg to 39.1. mmHg (p
AB - Nitric oxide (NO) is a potent vasodilator that regulates pulmonary vascular tone. During ascent to high altitude, pulmonary vascular tone increases leading to pulmonary hypertension. To explore the mechanisms underpinning this effect, we investigated the relationship between exhaled NO (PENO; nmHg) and pulmonary artery systolic pressure (PASP; mmHg) in 11 healthy adults during hypoxic challenge at sea level [with oxygen saturations (SPO2) of 80% and 90%] and at intervals during graded ascent to 5050. m. During normobaric hypoxia, PASP progressively increased from 22.7. mmHg to 33.5. mmHg (p=0.006), whilst PENO remained unchanged. In contrast, during ascent to high altitude, PASP increased progressively from 22.7. mmHg to 39.1. mmHg (p
UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-79959193730&md5=a137f2712140546fa02ca03ed1452494
U2 - 10.1016/j.resp.2011.04.008
DO - 10.1016/j.resp.2011.04.008
M3 - Article
AN - SCOPUS:79959193730
SN - 1569-9048
VL - 177
SP - 213
EP - 217
JO - Respiratory physiology & neurobiology
JF - Respiratory physiology & neurobiology
IS - 3
ER -