TY - JOUR
T1 - Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest
AU - Kiilerich, K
AU - Ringholm, S
AU - Bienso, RS
AU - Fisher, James
AU - Iversen, N
AU - van Hall, G
AU - Wojtaszewski, JFP
AU - Saltin, B
AU - Lundby, C
AU - Calbet, JAL
AU - Pilegaard, H
PY - 2011/9/1
Y1 - 2011/9/1
N2 - Kiilerich K, Ringholm S, Bienso RS, Fisher JP, Iversen N, van Hall G, Wojtaszewski JF, Saltin B, Lundby C, Calbet JA, Pilegaard H. Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest. J Appl Physiol 111: 751-757, 2011. First published June 16, 2011; doi: 10.1152/japplphysiol.00063.2011.-To test the hypothesis that physical inactivity impairs the exercise-induced modulation of pyruvate dehydrogenase (PDH), six healthy normally physically active male subjects completed 7 days of bed rest. Before and immediately after the bed rest, the subjects completed an oral glucose tolerance test (OGTT) and a one-legged knee extensor exercise bout [45 min at 60% maximal load (W-max)] with muscle biopsies obtained from vastus lateralis before, immediately after exercise, and at 3 h of recovery. Blood samples were taken from the femoral vein and artery before and after 40 min of exercise. Glucose intake elicited a larger (P
AB - Kiilerich K, Ringholm S, Bienso RS, Fisher JP, Iversen N, van Hall G, Wojtaszewski JF, Saltin B, Lundby C, Calbet JA, Pilegaard H. Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest. J Appl Physiol 111: 751-757, 2011. First published June 16, 2011; doi: 10.1152/japplphysiol.00063.2011.-To test the hypothesis that physical inactivity impairs the exercise-induced modulation of pyruvate dehydrogenase (PDH), six healthy normally physically active male subjects completed 7 days of bed rest. Before and immediately after the bed rest, the subjects completed an oral glucose tolerance test (OGTT) and a one-legged knee extensor exercise bout [45 min at 60% maximal load (W-max)] with muscle biopsies obtained from vastus lateralis before, immediately after exercise, and at 3 h of recovery. Blood samples were taken from the femoral vein and artery before and after 40 min of exercise. Glucose intake elicited a larger (P
KW - PDH
KW - physical inactivity
KW - human skeletal muscle
KW - glucose intolerance
U2 - 10.1152/japplphysiol.00063.2011
DO - 10.1152/japplphysiol.00063.2011
M3 - Article
C2 - 21680880
SN - 1522-1601
VL - 111
SP - 751
EP - 757
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 3
ER -