Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest

Research output: Contribution to journalArticle

Authors

  • K Kiilerich
  • S Ringholm
  • RS Bienso
  • N Iversen
  • G van Hall
  • JFP Wojtaszewski
  • B Saltin
  • C Lundby
  • JAL Calbet
  • H Pilegaard

Colleges, School and Institutes

Abstract

Kiilerich K, Ringholm S, Bienso RS, Fisher JP, Iversen N, van Hall G, Wojtaszewski JF, Saltin B, Lundby C, Calbet JA, Pilegaard H. Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest. J Appl Physiol 111: 751-757, 2011. First published June 16, 2011; doi: 10.1152/japplphysiol.00063.2011.-To test the hypothesis that physical inactivity impairs the exercise-induced modulation of pyruvate dehydrogenase (PDH), six healthy normally physically active male subjects completed 7 days of bed rest. Before and immediately after the bed rest, the subjects completed an oral glucose tolerance test (OGTT) and a one-legged knee extensor exercise bout [45 min at 60% maximal load (W-max)] with muscle biopsies obtained from vastus lateralis before, immediately after exercise, and at 3 h of recovery. Blood samples were taken from the femoral vein and artery before and after 40 min of exercise. Glucose intake elicited a larger (P

Details

Original languageEnglish
Pages (from-to)751-757
Number of pages7
JournalJournal of Applied Physiology
Volume111
Issue number3
Publication statusPublished - 1 Sep 2011

Keywords

  • PDH, physical inactivity, human skeletal muscle, glucose intolerance