Ex vivo reversal of in vivo transdifferentiation in mesothelial cells grown from peritoneal dialysate effluents

Regina Vargha; Michaela Endemann; Klaus Kratochwill; Andrea Riesenhuber; Nikolaus Wick; Anne-Marie Krachler; Laura Malaga-Dieguez; Christoph Aufricht

doi:10.1093/ndt/gfl355

Ex vivo reversal of in vivo transdifferentiation in mesothelial cells grown from peritoneal dialysate effluents

Regina Vargha, Michaela Endemann, Klaus Kratochwill, Andrea Riesenhuber, Nikolaus Wick, Anne-Marie Krachler, Laura Malaga-Dieguez, Christoph Aufricht

Biosciences

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

During peritoneal dialysis (PD), epithelial-mesenchymal transition (EMT) is likely involved in aberrant healing and progressive peritoneal fibrosis. Recently, EMT of the kidney was actively reversed into the opposite direction, into mesenchymal-epithelial transition (MET), by treatment with bone morphogenic protein-7 (BMP-7). In this study, the potential for ex vivo interconversion of in vivo transdifferentiation processes was investigated in mesothelial cells.

Original language	English
Pages (from-to)	2943-7
Number of pages	5
Journal	Nephrology, Dialysis, Transplantation
Volume	21
Issue number	10
DOIs	https://doi.org/10.1093/ndt/gfl355
Publication status	Published - Oct 2006

Keywords

Actins
Blotting, Western
Bone Morphogenetic Protein 7
Bone Morphogenetic Proteins
Cell Differentiation
Cells, Cultured
Child, Preschool
Cytoskeletal Proteins
Dialysis Solutions
Epithelial Cells
Female
Fibroblasts
Humans
Infant
Infant, Newborn
Male
Mesoderm
Peritoneal Dialysis
Reverse Transcriptase Polymerase Chain Reaction
Transforming Growth Factor beta

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10.1093/ndt/gfl355

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title = "Ex vivo reversal of in vivo transdifferentiation in mesothelial cells grown from peritoneal dialysate effluents",

abstract = "During peritoneal dialysis (PD), epithelial-mesenchymal transition (EMT) is likely involved in aberrant healing and progressive peritoneal fibrosis. Recently, EMT of the kidney was actively reversed into the opposite direction, into mesenchymal-epithelial transition (MET), by treatment with bone morphogenic protein-7 (BMP-7). In this study, the potential for ex vivo interconversion of in vivo transdifferentiation processes was investigated in mesothelial cells.",

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author = "Regina Vargha and Michaela Endemann and Klaus Kratochwill and Andrea Riesenhuber and Nikolaus Wick and Anne-Marie Krachler and Laura Malaga-Dieguez and Christoph Aufricht",

year = "2006",

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doi = "10.1093/ndt/gfl355",

language = "English",

volume = "21",

pages = "2943--7",

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TY - JOUR

T1 - Ex vivo reversal of in vivo transdifferentiation in mesothelial cells grown from peritoneal dialysate effluents

AU - Vargha, Regina

AU - Endemann, Michaela

AU - Kratochwill, Klaus

AU - Riesenhuber, Andrea

AU - Wick, Nikolaus

AU - Krachler, Anne-Marie

AU - Malaga-Dieguez, Laura

AU - Aufricht, Christoph

PY - 2006/10

Y1 - 2006/10

N2 - During peritoneal dialysis (PD), epithelial-mesenchymal transition (EMT) is likely involved in aberrant healing and progressive peritoneal fibrosis. Recently, EMT of the kidney was actively reversed into the opposite direction, into mesenchymal-epithelial transition (MET), by treatment with bone morphogenic protein-7 (BMP-7). In this study, the potential for ex vivo interconversion of in vivo transdifferentiation processes was investigated in mesothelial cells.

AB - During peritoneal dialysis (PD), epithelial-mesenchymal transition (EMT) is likely involved in aberrant healing and progressive peritoneal fibrosis. Recently, EMT of the kidney was actively reversed into the opposite direction, into mesenchymal-epithelial transition (MET), by treatment with bone morphogenic protein-7 (BMP-7). In this study, the potential for ex vivo interconversion of in vivo transdifferentiation processes was investigated in mesothelial cells.

KW - Actins

KW - Blotting, Western

KW - Bone Morphogenetic Protein 7

KW - Bone Morphogenetic Proteins

KW - Cell Differentiation

KW - Cells, Cultured

KW - Child, Preschool

KW - Cytoskeletal Proteins

KW - Dialysis Solutions

KW - Epithelial Cells

KW - Female

KW - Fibroblasts

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Mesoderm

KW - Peritoneal Dialysis

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Transforming Growth Factor beta

U2 - 10.1093/ndt/gfl355

DO - 10.1093/ndt/gfl355

M3 - Article

C2 - 16861732

SN - 0931-0509

VL - 21

SP - 2943

EP - 2947

JO - Nephrology, Dialysis, Transplantation

JF - Nephrology, Dialysis, Transplantation

IS - 10

ER -

Ex vivo reversal of in vivo transdifferentiation in mesothelial cells grown from peritoneal dialysate effluents

Abstract

Keywords

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