Ex vivo reversal of in vivo transdifferentiation in mesothelial cells grown from peritoneal dialysate effluents

Research output: Contribution to journalArticlepeer-review

Authors

  • Regina Vargha
  • Michaela Endemann
  • Klaus Kratochwill
  • Andrea Riesenhuber
  • Nikolaus Wick
  • Laura Malaga-Dieguez
  • Christoph Aufricht

Colleges, School and Institutes

Abstract

During peritoneal dialysis (PD), epithelial-mesenchymal transition (EMT) is likely involved in aberrant healing and progressive peritoneal fibrosis. Recently, EMT of the kidney was actively reversed into the opposite direction, into mesenchymal-epithelial transition (MET), by treatment with bone morphogenic protein-7 (BMP-7). In this study, the potential for ex vivo interconversion of in vivo transdifferentiation processes was investigated in mesothelial cells.

Details

Original languageEnglish
Pages (from-to)2943-7
Number of pages5
JournalNephrology, Dialysis, Transplantation
Volume21
Issue number10
Publication statusPublished - Oct 2006

Keywords

  • Actins, Blotting, Western, Bone Morphogenetic Protein 7, Bone Morphogenetic Proteins, Cell Differentiation, Cells, Cultured, Child, Preschool, Cytoskeletal Proteins, Dialysis Solutions, Epithelial Cells, Female, Fibroblasts, Humans, Infant, Infant, Newborn, Male, Mesoderm, Peritoneal Dialysis, Reverse Transcriptase Polymerase Chain Reaction, Transforming Growth Factor beta