Evolution of bacterial transcription factors: how proteins take on new tasks, but do not always stop doing the old ones

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Colleges, School and Institutes


Many bacterial transcription factors do not behave as per the textbook operon model. We draw on whole genome work, as well as reported diversity across different bacteria, to argue that transcription factors may have evolved from nucleoid-associated proteins. This view would explain a large amount of recent data gleaned from high-throughput sequencing and bioinformatic analyses.

Bibliographic note

Copyright © 2015 Elsevier Ltd. All rights reserved.


Original languageEnglish
JournalTrends in Microbiology
Publication statusPublished - 20 May 2015