Evidence of acceptability of oral paediatric medicines: a review

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Colleges, School and Institutes

Abstract

Objectives

The aim of this review was to map the currently available evidence on acceptability of oral paediatric medicines to aid in the selection of suitable platform formulations for the development of new acceptable paediatric products.

Methods

This process used a defined search strategy of indexed publications and included methods to assess the quality of the evidence retrieved.

Key Findings

Taste/palatability was the most extensively studied area of paediatric medicine acceptability yet standard methods or criteria that define what is classed as acceptable to children is still to be defined. There have been many reports on the acceptability of medicines to paediatric populations yet major gaps in the acceptability knowledge base exist including: the shape and dimensions of
tablets, minitablets and capsules swallowed whole in infants and children; size and overall volume of multiparticulates; volume of liquids completely swallowed in infants and children; duration of retention within the oral cavity, size and taste of orodispersible tablets, lozenges and chewable tablets and the number of solid units dosed at each timepoint.

Conclusions

The review highlights where further information is required to support knowledge around acceptability of age appropriate medicines. An algorithm to aid in selection of a formulation that is likely to be acceptable based on the age range to be treated by the medicine is presented as a result of this review.

Details

Original languageEnglish
JournalJournal of Pharmacy and Pharmacology
Early online date14 Aug 2016
Publication statusE-pub ahead of print - 14 Aug 2016

Keywords

  • Paediatric medicine , acceptability , tablet , liquid , minitablet