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Abstract
AIMS: Lysyl oxidase (LOX) expression is elevated in colorectal cancer (CRC) tissue and associated with disease progression. A blood test may form a more acceptable diagnostic test for CRC although LOX has not previously been measured in the serum. We therefore sought to determine the clinical usefulness of a serum LOX test for CRC in a symptomatic population.
METHODS: Adult patients referred to a hospital colorectal clinic with bowel symptoms completed a questionnaire and provided a blood sample for serum LOX measurement. Associations between presenting symptoms, serum LOX concentrations and outcomes of investigations were tested by univariate and multivariate analyses to determine if serum LOX was clinically useful in the prediction of CRC. LOX expression in CRC and adjacent colon biopsies was evaluated by ELISA and immunohistochemistry.
RESULTS: Thirty-one cases of colorectal cancer and 16 high-risk polyps were identified from a total of 962 participants. There was no association between serum LOX concentration and the presence of CRC, high-risk polyps or cancers at any site. LOX expression was significantly increased in CRC tissue compared to adjacent colon.
CONCLUSION: Despite overexpression of LOX in CRC tissue, elevated serum levels could not be demonstrated. Serum LOX measurement is therefore not a clinically useful test for CRC.
Original language | English |
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Pages (from-to) | 731-8 |
Number of pages | 8 |
Journal | European Journal of Surgical Oncology |
Volume | 40 |
Issue number | 6 |
Early online date | 6 Nov 2013 |
DOIs | |
Publication status | Published - 1 Jun 2014 |
Bibliographical note
Copyright © 2013 Elsevier Ltd. All rights reserved.Keywords
- Adult
- Aged
- Colorectal Neoplasms
- Disease Progression
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Protein-Lysine 6-Oxidase
- Questionnaires
Fingerprint
Dive into the research topics of 'Evaluation of serum lysyl oxidase as a blood test for colorectal cancer'. Together they form a unique fingerprint.Projects
- 4 Finished
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Tissue-Specific Recruitment of Regulatory T Cells in Colorectal Cancer and Liver Metastases
3/10/12 → 2/10/14
Project: Research Councils
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Pre-Clinical Study of Hepatocyte Transplantation Using Human Embryonic Stem Cell-Derived Hepatocytes
6/07/09 → 5/07/12
Project: Research Councils
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Adhesion receptors in the vasculature: from mouse to human
1/04/04 → 31/03/09
Project: Research Councils
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Lymphocyte Ligands for the Endothelial Adhesion Molecule Vascular Adhesion Protein-1
Adams, D. & Wakelam, M.
15/01/04 → 31/03/07
Project: Research Councils