TY - JOUR
T1 - Evaluation of a non-invasive method of assessing opoid induced respiratory depression
AU - Pattinson, KTS
AU - Bowes, M
AU - Wise, Richard
AU - Parkes, Michael
AU - Morrell, MJ
PY - 2005/5/1
Y1 - 2005/5/1
N2 - Opioid induced respiratory depression is potentially fatal. The aim of this study was to validate a monitoring system that could be used to assess respiratory depression in postoperative patients. The hypercapnic ventilatory response was estimated non-invasively in 12 volunteers. In two steps, we tested a system which delivered carbon dioxide (CO(2)) challenges through a venturi mask, measuring changes in ventilation with an uncalibrated respiratory inductance plethysmograph (RIP). RIP and pneumotachograph measurements of ventilation, taken at the same time during a CO(2) challenge, were similar; group mean (SD), pneumotachograph 13.9 (3.5) l x min(-1) x kPa(-1), RIP 14.3 (2.9) l x min(-1) x kPa(-1). Bland-Altmann analysis showed the variation between these two methods was +/- 5 l x min(-1) x kPa(-1) (2 SD). Second, we confirmed that the venturi mask is suitable for delivering CO(2) challenges. Despite the variability in RIP measurements, a simple multimodal respiratory monitoring system could be developed that incorporates clinical observation and non-invasive measurement of the ventilatory response to CO(2).
AB - Opioid induced respiratory depression is potentially fatal. The aim of this study was to validate a monitoring system that could be used to assess respiratory depression in postoperative patients. The hypercapnic ventilatory response was estimated non-invasively in 12 volunteers. In two steps, we tested a system which delivered carbon dioxide (CO(2)) challenges through a venturi mask, measuring changes in ventilation with an uncalibrated respiratory inductance plethysmograph (RIP). RIP and pneumotachograph measurements of ventilation, taken at the same time during a CO(2) challenge, were similar; group mean (SD), pneumotachograph 13.9 (3.5) l x min(-1) x kPa(-1), RIP 14.3 (2.9) l x min(-1) x kPa(-1). Bland-Altmann analysis showed the variation between these two methods was +/- 5 l x min(-1) x kPa(-1) (2 SD). Second, we confirmed that the venturi mask is suitable for delivering CO(2) challenges. Despite the variability in RIP measurements, a simple multimodal respiratory monitoring system could be developed that incorporates clinical observation and non-invasive measurement of the ventilatory response to CO(2).
UR - http://www.scopus.com/inward/record.url?scp=17844389568&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2044.2005.04153.x
DO - 10.1111/j.1365-2044.2005.04153.x
M3 - Article
C2 - 15819760
SN - 1365-2044
SN - 1365-2044
SN - 1365-2044
SN - 1365-2044
SN - 1365-2044
SN - 1365-2044
SN - 1365-2044
SN - 1365-2044
SN - 1365-2044
VL - 60
SP - 426
EP - 432
JO - Anaesthesia
JF - Anaesthesia
ER -