Evaluation of a non-invasive method of assessing opoid induced respiratory depression

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Evaluation of a non-invasive method of assessing opoid induced respiratory depression. / Pattinson, KTS; Bowes, M; Wise, Richard; Parkes, Michael; Morrell, MJ.

In: Anaesthesia, Vol. 60, 01.05.2005, p. 426-432.

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Pattinson, KTS ; Bowes, M ; Wise, Richard ; Parkes, Michael ; Morrell, MJ. / Evaluation of a non-invasive method of assessing opoid induced respiratory depression. In: Anaesthesia. 2005 ; Vol. 60. pp. 426-432.

Bibtex

@article{7fb623bc4bf847faaac769a7dea5078c,
title = "Evaluation of a non-invasive method of assessing opoid induced respiratory depression",
abstract = "Opioid induced respiratory depression is potentially fatal. The aim of this study was to validate a monitoring system that could be used to assess respiratory depression in postoperative patients. The hypercapnic ventilatory response was estimated non-invasively in 12 volunteers. In two steps, we tested a system which delivered carbon dioxide (CO(2)) challenges through a venturi mask, measuring changes in ventilation with an uncalibrated respiratory inductance plethysmograph (RIP). RIP and pneumotachograph measurements of ventilation, taken at the same time during a CO(2) challenge, were similar; group mean (SD), pneumotachograph 13.9 (3.5) l x min(-1) x kPa(-1), RIP 14.3 (2.9) l x min(-1) x kPa(-1). Bland-Altmann analysis showed the variation between these two methods was +/- 5 l x min(-1) x kPa(-1) (2 SD). Second, we confirmed that the venturi mask is suitable for delivering CO(2) challenges. Despite the variability in RIP measurements, a simple multimodal respiratory monitoring system could be developed that incorporates clinical observation and non-invasive measurement of the ventilatory response to CO(2).",
author = "KTS Pattinson and M Bowes and Richard Wise and Michael Parkes and MJ Morrell",
year = "2005",
month = may,
day = "1",
doi = "10.1111/j.1365-2044.2005.04153.x",
language = "English",
volume = "60",
pages = "426--432",
journal = "Anaesthesia",
issn = "0003-2409",
publisher = "Wiley",

}

RIS

TY - JOUR

T1 - Evaluation of a non-invasive method of assessing opoid induced respiratory depression

AU - Pattinson, KTS

AU - Bowes, M

AU - Wise, Richard

AU - Parkes, Michael

AU - Morrell, MJ

PY - 2005/5/1

Y1 - 2005/5/1

N2 - Opioid induced respiratory depression is potentially fatal. The aim of this study was to validate a monitoring system that could be used to assess respiratory depression in postoperative patients. The hypercapnic ventilatory response was estimated non-invasively in 12 volunteers. In two steps, we tested a system which delivered carbon dioxide (CO(2)) challenges through a venturi mask, measuring changes in ventilation with an uncalibrated respiratory inductance plethysmograph (RIP). RIP and pneumotachograph measurements of ventilation, taken at the same time during a CO(2) challenge, were similar; group mean (SD), pneumotachograph 13.9 (3.5) l x min(-1) x kPa(-1), RIP 14.3 (2.9) l x min(-1) x kPa(-1). Bland-Altmann analysis showed the variation between these two methods was +/- 5 l x min(-1) x kPa(-1) (2 SD). Second, we confirmed that the venturi mask is suitable for delivering CO(2) challenges. Despite the variability in RIP measurements, a simple multimodal respiratory monitoring system could be developed that incorporates clinical observation and non-invasive measurement of the ventilatory response to CO(2).

AB - Opioid induced respiratory depression is potentially fatal. The aim of this study was to validate a monitoring system that could be used to assess respiratory depression in postoperative patients. The hypercapnic ventilatory response was estimated non-invasively in 12 volunteers. In two steps, we tested a system which delivered carbon dioxide (CO(2)) challenges through a venturi mask, measuring changes in ventilation with an uncalibrated respiratory inductance plethysmograph (RIP). RIP and pneumotachograph measurements of ventilation, taken at the same time during a CO(2) challenge, were similar; group mean (SD), pneumotachograph 13.9 (3.5) l x min(-1) x kPa(-1), RIP 14.3 (2.9) l x min(-1) x kPa(-1). Bland-Altmann analysis showed the variation between these two methods was +/- 5 l x min(-1) x kPa(-1) (2 SD). Second, we confirmed that the venturi mask is suitable for delivering CO(2) challenges. Despite the variability in RIP measurements, a simple multimodal respiratory monitoring system could be developed that incorporates clinical observation and non-invasive measurement of the ventilatory response to CO(2).

UR - http://www.scopus.com/inward/record.url?scp=17844389568&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2044.2005.04153.x

DO - 10.1111/j.1365-2044.2005.04153.x

M3 - Article

C2 - 15819760

VL - 60

SP - 426

EP - 432

JO - Anaesthesia

JF - Anaesthesia

SN - 0003-2409

ER -